UniProt Accession

 CN37_RAT; P13233; Q4V796; Q64575 

Genbank Protein ID

 M18630; L16532; BC098066 

Genbank Nucleotide ID

 AAA40939.1; AAA64429.1; AAH98066.1 

Protein Name

 2',3'-cyclic-nucleotide 3'-phosphodiesterase 

Protein Synonyms/Alias

 CNP; CNPase 

Gene Name

 Cnp 

Gene Synonyms/Alias

 Cnp1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
15	KSHTFLPKIFFRKMS	acetylation	[1]
29	SSSGAKDKPELQFPF	acetylation	[1]
73	LARLIVEKYHNGTKM	acetylation	[1]
73	LARLIVEKYHNGTKM	ubiquitination	[2]
87	MVSADAYKIIPGSRA	acetylation	[1]
87	MVSADAYKIIPGSRA	ubiquitination	[2]
101	ADFSEEYKRLDEDLA	acetylation	[1]
101	ADFSEEYKRLDEDLA	ubiquitination	[2]
161	RLDCAQLKEKNQWQL	acetylation	[1]
163	DCAQLKEKNQWQLSL	acetylation	[1]
163	DCAQLKEKNQWQLSL	ubiquitination	[2]
174	QLSLDDLKKLKPGLE	acetylation	[1]
174	QLSLDDLKKLKPGLE	ubiquitination	[2]
175	LSLDDLKKLKPGLEK	ubiquitination	[2]
177	LDDLKKLKPGLEKDF	acetylation	[1]
195	YFGWFLTKKSSETLR	acetylation	[1]
216	LEELGNHKAFKKELR	acetylation	[1]
216	LEELGNHKAFKKELR	ubiquitination	[2]
220	GNHKAFKKELRHFIS	acetylation	[1]
232	FISGDEPKEKLDLVS	acetylation	[1]
232	FISGDEPKEKLDLVS	ubiquitination	[2]
234	SGDEPKEKLDLVSYF	acetylation	[1]
234	SGDEPKEKLDLVSYF	ubiquitination	[2]
243	DLVSYFGKRPPGVLH	acetylation	[1]
254	GVLHCTTKFCDYGKA	acetylation	[1]
260	TKFCDYGKATGAEEY	acetylation	[1]
279	VVRRSYGKAFKLSIS	acetylation	[1]
315	LWPSDLDKPSSSESL	acetylation	[1]
370	VGELPRGKLYSLGKG	acetylation	[1]
376	GKLYSLGKGRWMLSL	acetylation	[1]
376	GKLYSLGKGRWMLSL	ubiquitination	[2]
385	RWMLSLAKKMEVKAI	acetylation	[1]
399	IFTGYYGKGKPVPVH	acetylation	[1]
401	TGYYGKGKPVPVHGS	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity). 

Sequence Annotation

 ACT_SITE 250 250 Proton acceptor.
 ACT_SITE 329 329 Proton donor.
 BINDING 252 252 Substrate (By similarity).
 BINDING 331 331 Substrate (By similarity).
 MOD_RES 110 110 Phosphotyrosine (By similarity).
 MOD_RES 372 372 Phosphotyrosine (By similarity).
 MOD_RES 417 417 Cysteine methyl ester (Probable).
 LIPID 417 417 S-farnesyl cysteine (Probable).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Hydrolase; Lipoprotein; Membrane; Methylation; Phosphoprotein; Prenylation; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 420 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005902; C:microvillus; IDA:RGD.
 GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
 GO:0005741; C:mitochondrial outer membrane; IDA:RGD.
 GO:0035748; C:myelin sheath abaxonal region; IDA:RGD.
 GO:0035749; C:myelin sheath adaxonal region; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0031143; C:pseudopodium; IDA:RGD.
 GO:0004113; F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; IDA:RGD.
 GO:0030551; F:cyclic nucleotide binding; IDA:RGD.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0007568; P:aging; IEP:RGD.
 GO:0007409; P:axonogenesis; IEA:Compara.
 GO:0009214; P:cyclic nucleotide catabolic process; IEA:InterPro.
 GO:0030900; P:forebrain development; IEP:RGD.
 GO:0000226; P:microtubule cytoskeleton organization; IMP:RGD.
 GO:0046902; P:regulation of mitochondrial membrane permeability; IMP:RGD.
 GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 

Interpro

 IPR008431; CNPase.
 IPR027417; P-loop_NTPase.
 IPR009097; RNA_ligase/cNuc_Pdiesterase. 

Pfam

 PF05881; CNPase 

SMART

  

PROSITE

  

PRINTS