UniProt Accession

 CPLX1_HUMAN; O14810; A6NI80; B2R4R5; D3DVN3 

Genbank Protein ID

 AF022383; BT007029; AK311921; AC139887; CH471131; CH471131; BC002471 

Genbank Nucleotide ID

 AAB72108.1; AAP35676.1; BAG34862.1; EAW82648.1; EAW82649.1; AAH02471.1 

Protein Name

 Complexin-1 

Protein Synonyms/Alias

 Complexin I; CPX I; Synaphin-2 

Gene Name

 CPLX1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
14	QALGGATKDMGKMLG	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity). 

Sequence Annotation

 REGION 48 70 Interaction with the SNARE complex (By  

Keyword

 3D-structure; Coiled coil; Complete proteome; Cytoplasm; Exocytosis; Neurotransmitter transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 134 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IEA:Compara.
 GO:0005326; F:neurotransmitter transporter activity; IEA:Compara.
 GO:0006887; P:exocytosis; TAS:ProtInc.
 GO:0014047; P:glutamate secretion; TAS:Reactome.
 GO:0030073; P:insulin secretion; IEA:Compara.
 GO:0007269; P:neurotransmitter secretion; TAS:Reactome.
 GO:0016079; P:synaptic vesicle exocytosis; IEA:Compara. 

Interpro

 IPR008849; Synaphin. 

Pfam

 PF05835; Synaphin 

SMART

  

PROSITE

  

PRINTS