UniProt Accession

 MAP1_YEAST; Q01662; D6VYP2 

Genbank Protein ID

 M77092; U20865; BK006945 

Genbank Nucleotide ID

 AAA75193.1; AAB67398.1; DAA09558.1 

Protein Name

 Methionine aminopeptidase 1 

Protein Synonyms/Alias

 MAP 1; MetAP 1; Peptidase M 1 

Gene Name

 MAP1 

Gene Synonyms/Alias

 YLR244C; L9672.12 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
36	RETSSQMKCPVCLKQ	ubiquitination	[1]
81	GAYDPFPKFKYSGKV	acetylation	[2]
131	LNNIPIYKKDQIKKI	acetylation	[2]
278	ELGDHIEKHATENKC	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays the major role in N-terminal methionine removal. Less efficient when the second residue is Val. 

Sequence Annotation

 REGION 22 66 Zinc finger-like; important for proper
 METAL 219 219 Divalent metal cation 1 (By similarity).
 METAL 230 230 Divalent metal cation 1 (By similarity).
 METAL 230 230 Divalent metal cation 2; catalytic (By
 METAL 294 294 Divalent metal cation 2; catalytic; via
 METAL 327 327 Divalent metal cation 2; catalytic (By
 METAL 358 358 Divalent metal cation 1 (By similarity).
 METAL 358 358 Divalent metal cation 2; catalytic (By
 BINDING 202 202 Substrate (By similarity).
 BINDING 301 301 Substrate (By similarity).  

Keyword

 Aminopeptidase; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Metal-binding; Protease; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 387 AA 

Protein Sequence

Gene Ontology

 GO:0022626; C:cytosolic ribosome; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0070006; F:metalloaminopeptidase activity; IDA:SGD.
 GO:0003729; F:mRNA binding; IDA:SGD.
 GO:0010629; P:negative regulation of gene expression; IMP:SGD.
 GO:0035551; P:protein initiator methionine removal involved in protein maturation; IMP:SGD.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR001714; Pept_M24_MAP.
 IPR000994; Pept_M24_structural-domain.
 IPR002467; Pept_M24A_MAP1. 

Pfam

 PF00557; Peptidase_M24 

SMART

  

PROSITE

 PS00680; MAP_1 

PRINTS

 PR00599; MAPEPTIDASE.