UniProt Accession

 E9QMC5_MOUSE; E9QMC5 

Genbank Protein ID

 AL672241 

Genbank Nucleotide ID

  

Protein Name

 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 

Protein Synonyms/Alias

  

Gene Name

 Ptpmt1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
152	RFLCNTSKEWKKAGV	acetylation	[1, 2]
152	RFLCNTSKEWKKAGV	succinylation	[2]
251	EVLKEFHKEITARAA	acetylation	[3]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
 GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:MGI.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:RefGenome.
 GO:0046855; P:inositol phosphate dephosphorylation; IBA:RefGenome.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
 GO:0046488; P:phosphatidylinositol metabolic process; IC:MGI. 

Interpro

 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR024950; DUSP.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS. 

Pfam

 PF00782; DSPc 

SMART

  

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2 

PRINTS