CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041525
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polyribonucleotide nucleotidyltransferase 1 
Protein Synonyms/Alias
 Protein Pnpt1 
Gene Name
 Pnpt1 
Gene Synonyms/Alias
 rCG_23251 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
250HAIKVGVKYTQQIIQacetylation[1]
264QSIQQLVKEIGVAKRacetylation[1]
306FTDYEHDKVSRDEAVacetylation[1]
562TALQADIKLPGVPVKacetylation[1]
569KLPGVPVKIIMEAIQacetylation[1]
591EILQTMSKTISKPRAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 784 AA 
Protein Sequence
MAACRPCCLC LCLRPLSCGP LGRPRRHRAL SYLQVRALWS GTRSRAVTVD LGHRKLEISS 60
GKLARFADGC AVVQSGDTAV MVTAVSKTKP SPSQFMPLVV DYRQKAAAAG RIPTNYLRRE 120
IGSSDKEILT SRVIDRSIRP LFPAGYFYDT QVLCNLLAVD GINEPDILAI NGASAALSLS 180
DIPWNGPVGA VRIGMIDGEC VVNPTRKEMS SSTLNLVVAG APKSQIVMLE ASAENILQQD 240
FCHAIKVGVK YTQQIIQSIQ QLVKEIGVAK RTPQKIFTPS AEIVKYTHTI AMEKLYAVFT 300
DYEHDKVSRD EAVNKIRLDT EEHLKEKFPE VDQLEIIESF NVVAKEVFRS IILNEYKRCD 360
GRDLTSLRNI SCEVDMFKTL HGSALFQRGQ TQVLCTVTFD SLESSIKSDQ IITAINGVKD 420
KNFMLHYEFP PYATNETGKV TGVNRRELGH GALAEKALCP VIPKDFPFTI RVTSEVLESN 480
GSSSMASACG GSLALMDAGV PISSAVAGVA VGLVTKSNPE KGEIEDYRLL TDILGIEDYN 540
GDMDFKIAGT NKGITALQAD IKLPGVPVKI IMEAIQQATV AKREILQTMS KTISKPRASR 600
KENGPVVETV KVPLSKRAKF IGPGGYHLKK LQAETGVTIS QVDEETFSIF APTPTAMHEA 660
RDFITEICRD DQEQQLEFGA VYTATITEIR DTGVMVKLYP NMTAVLLHNS QLDQRKIKHP 720
TALGLEVGQE IQVKYFGRDP ADGRMRLSRK VLQSPATTVL KTLNDRSSIV MGEPISQSSS 780
NSSP 784 
Gene Ontology
 GO:0045025; C:mitochondrial degradosome; IEA:Compara.
 GO:0005758; C:mitochondrial intermembrane space; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0000175; F:3'-5'-exoribonuclease activity; IEA:Compara.
 GO:0035198; F:miRNA binding; IEA:Compara.
 GO:0034046; F:poly(G) RNA binding; IEA:Compara.
 GO:0008266; F:poly(U) RNA binding; IEA:Compara.
 GO:0004654; F:polyribonucleotide nucleotidyltransferase activity; IEA:Compara.
 GO:0035458; P:cellular response to interferon-beta; IEA:Compara.
 GO:0034599; P:cellular response to oxidative stress; IEA:Compara.
 GO:0000958; P:mitochondrial mRNA catabolic process; IEA:Compara.
 GO:0097222; P:mitochondrial mRNA polyadenylation; IEA:Compara.
 GO:0000965; P:mitochondrial RNA 3'-end processing; IEA:Compara.
 GO:0000964; P:mitochondrial RNA 5'-end processing; IEA:Compara.
 GO:0070584; P:mitochondrion morphogenesis; IEA:Compara.
 GO:0071850; P:mitotic cell cycle arrest; IEA:Compara.
 GO:0045926; P:negative regulation of growth; IEA:Compara.
 GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; IEA:Compara.
 GO:2000627; P:positive regulation of miRNA catabolic process; IEA:Compara.
 GO:0000962; P:positive regulation of mitochondrial RNA catabolic process; IEA:Compara.
 GO:0061014; P:positive regulation of mRNA catabolic process; IEA:Compara.
 GO:0070207; P:protein homotrimerization; IEA:Compara.
 GO:0043457; P:regulation of cellular respiration; IEA:Compara.
 GO:2000772; P:regulation of cellular senescence; IEA:Compara.
 GO:0035928; P:rRNA import into mitochondrion; IEA:Compara. 
Interpro
 IPR001247; ExoRNase_PH_dom1.
 IPR015847; ExoRNase_PH_dom2.
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1.
 IPR012340; NA-bd_OB-fold.
 IPR012162; PNPase.
 IPR027408; PNPase/RNase_PH_dom.
 IPR015848; PNPase_PH_RNA-bd_bac/org-type.
 IPR003029; Rbsml_prot_S1_RNA-bd_dom.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR022967; RNA-binding_domain_S1. 
Pfam
 PF00013; KH_1
 PF03726; PNPase
 PF01138; RNase_PH
 PF03725; RNase_PH_C
 PF00575; S1 
SMART
 SM00322; KH
 SM00316; S1 
PROSITE
 PS50084; KH_TYPE_1
 PS50126; S1 
PRINTS