UniProt Accession

 G3V2N6_HUMAN; G3V2N6 

Genbank Protein ID

 AC092143; CH471184 

Genbank Nucleotide ID

 EAW66672.1 

Protein Name

 HCG1983504, isoform CRA_d 

Protein Synonyms/Alias

 Tubulin beta-3 chain 

Gene Name

 TUBB3 

Gene Synonyms/Alias

 hCG_1983504 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	YNEASSHKYVPRAIL	acetylation	[1]
58	YNEASSHKYVPRAIL	ubiquitination	[2, 3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; GTP-binding; Microtubule; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 164 AA 

Protein Sequence

Gene Ontology

 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
 GO:0007017; P:microtubule-based process; IEA:InterPro.
 GO:0051258; P:protein polymerization; IEA:InterPro. 

Interpro

 IPR013838; Beta-tubulin_BS.
 IPR002453; Beta_tubulin.
 IPR000217; Tubulin.
 IPR003008; Tubulin_FtsZ_GTPase. 

Pfam

 PF00091; Tubulin 

SMART

  

PROSITE

 PS00228; TUBULIN_B_AUTOREG 

PRINTS

 PR01163; BETATUBULIN.
 PR01161; TUBULIN.