| Tag | Content |
|---|
| CPLM ID | CPLM-021760 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Equilibrative nucleoside transporter 1 |
Protein Synonyms/Alias | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1 |
Gene Name | Slc29a1 |
Gene Synonyms/Alias | Ent1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 249 | GPAEQETKLDLIREE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs). |
Sequence Annotation | CARBOHYD 48 48 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 460 AA |
Protein Sequence | MTTSHQPQDR YKAVWLIFFV LGLGTLLPWN FFMTATKYFT NRLDVSQNVS SDTDQSCEST 60
KALADPTVAL PARSSLSAIF NNVMTLCAML PLLVFTCLNS FLHQRISQSV RILGSLLAIL 120
LVFLVTAALV KVEMDALIFF VITMIKIVLI NSFGAILQAS LFGLAGVLPA NYTAPIMSGQ 180
GLAGFFTSVA MICAIASGSE LSESAFGYFI TACAVVILAI LCYLALPRTE FYRHYLQLNL 240
AGPAEQETKL DLIREEPKGR REESGVPGPN SPPTNRNQSI KAILKSICVP ALSVCFIFTV 300
TIGLFPAVTA EVESSIAGTS PWKSYFIPVA CFLNFNVFDW LGRSLTAVCM WPGQDSRWLP 360
VLVASRIVFI PLLMLCNVKA RHCGAQRHHF VFKHDAWFIA FMAAFAFSNG YLASLCMCFG 420
PKKVKPAEAE TAGNIMSFFL CLGLALGAVL SFLLRALV 458 |
Gene Ontology | GO:0016324; C:apical plasma membrane; ISS:UniProtKB. GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005337; F:nucleoside transmembrane transporter activity; IDA:MGI. GO:0071333; P:cellular response to glucose stimulus; IEA:Compara. GO:0071456; P:cellular response to hypoxia; IEA:Compara. GO:0007595; P:lactation; IEA:Compara. GO:0015858; P:nucleoside transport; IDA:MGI. GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara. GO:0030431; P:sleep; IEA:Compara. GO:0015862; P:uridine transport; IEA:Compara. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |