UniProt Accession

 CBR4_RAT; Q7TS56 

Genbank Protein ID

 AY305858; BC086378 

Genbank Nucleotide ID

 AAP70488.1; AAH86378.1 

Protein Name

 Carbonyl reductase family member 4 

Protein Synonyms/Alias

 3-oxoacyl-[acyl-carrier-protein] reductase; Quinone reductase CBR4 

Gene Name

 Cbr4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
189	TDMTKHLKEEHFKKN	acetylation	[1]
194	HLKEEHFKKNIPLGR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (By similarity). 

Sequence Annotation

 NP_BIND 7 31 NAD or NADP (By similarity).
 ACT_SITE 147 147 Proton acceptor (By similarity).
 BINDING 134 134 Substrate (By similarity).  

Keyword

 Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Mitochondrion; NAD; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
 GO:0070402; F:NADPH binding; ISS:UniProtKB.
 GO:0008753; F:NADPH dehydrogenase (quinone) activity; ISS:UniProtKB.
 GO:0048038; F:quinone binding; ISS:UniProtKB.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.