Tag | Content |
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CPLM ID | CPLM-007777 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synaptotagmin-2 |
Protein Synonyms/Alias | Synaptotagmin II; SytII |
Gene Name | Syt2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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112 | MKNAMNMKDMKGGQD | ubiquitination | [1] | 268 | RDLQGGEKEEPEKLG | ubiquitination | [1] | 289 | RYVPTAGKLTVCILE | ubiquitination | [1] | 298 | TVCILEAKNLKKMDV | ubiquitination | [1] | 367 | VTVLDYDKLGKNEAI | ubiquitination | [1] | 376 | GKNEAIGKIFVGSNA | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. |
Sequence Annotation | DOMAIN 156 245 C2 1. DOMAIN 287 378 C2 2. REGION 136 382 Phospholipid binding (Probable). METAL 172 172 Calcium 2; via carbonyl oxygen (By METAL 173 173 Calcium 1 (By similarity). METAL 173 173 Calcium 2 (By similarity). METAL 179 179 Calcium 1 (By similarity). METAL 231 231 Calcium 1 (By similarity). METAL 231 231 Calcium 2 (By similarity). METAL 232 232 Calcium 1; via carbonyl oxygen (By METAL 233 233 Calcium 1 (By similarity). METAL 233 233 Calcium 2 (By similarity). METAL 233 233 Calcium 3 (By similarity). METAL 236 236 Calcium 3 (By similarity). METAL 237 237 Calcium 3; via carbonyl oxygen (By METAL 239 239 Calcium 2 (By similarity). METAL 239 239 Calcium 3 (By similarity). CARBOHYD 32 32 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Calcium; Cell junction; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 422 AA |
Protein Sequence | MRNIFKRNQE PNVAPATTTA TMPLAPVAPA DNSTESTGPG ESQEDMFAKL KEKFFNEINK 60 IPLPPWALIA MAVVAGLLLL TCCFCICKKC CCKKKKNKKE KGKGMKNAMN MKDMKGGQDD 120 DDAETGLTEG EGEGEEEKEP ENLGKLQFSL DYDFQANQLT VGVLQAAELP ALDMGGTSDP 180 YVKVFLLPDK KKKYETKVHR KTLNPAFNET FTFKVPYQEL AGKTLVMAIY DFDRFSKHDI 240 IGEVKVPMNT VDLGQPIEEW RDLQGGEKEE PEKLGDICTS LRYVPTAGKL TVCILEAKNL 300 KKMDVGGLSD PYVKIHLMQN GKRLKKKKTT VKKKTLNPYF NESFSFEIPF EQIQKVQVVV 360 TVLDYDKLGK NEAIGKIFVG SNATGTELRH WSDMLANPRR PIAQWHSLKP EEEVDALLGK 420 NK 422 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IDA:MGI. GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IDA:MGI. GO:0005544; F:calcium-dependent phospholipid binding; IDA:MGI. GO:0005215; F:transporter activity; IEA:InterPro. |
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