UniProt Accession

 DIM1_MOUSE; Q9D0D4; Q3TTJ5; Q8BVH8 

Genbank Protein ID

 AK011544; AK078186; AK161333; BC019799 

Genbank Nucleotide ID

 BAB27687.1; BAC37166.1; BAE36330.1; AAH19799.1 

Protein Name

 Probable dimethyladenosine transferase 

Protein Synonyms/Alias

 DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1-like; Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; Probable 18S rRNA dimethylase; Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase 

Gene Name

 Dimt1 

Gene Synonyms/Alias

 Dimt1l 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
253	AVQQLLEKNYRIHCS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (By similarity). 

Sequence Annotation

 BINDING 37 37 S-adenosyl-L-methionine; via carbonyl
 BINDING 39 39 S-adenosyl-L-methionine; via amide
 BINDING 64 64 S-adenosyl-L-methionine; via carbonyl
 BINDING 85 85 S-adenosyl-L-methionine (By similarity).
 BINDING 113 113 S-adenosyl-L-methionine (By similarity).
 BINDING 128 128 S-adenosyl-L-methionine (By similarity).  

Keyword

 Complete proteome; Methyltransferase; Nucleus; Reference proteome; RNA-binding; rRNA processing; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 313 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0052909; F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity; IEA:EC.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000179; F:rRNA (adenine-N6,N6-)-dimethyltransferase activity; IEA:InterPro.
 GO:0031167; P:rRNA methylation; IEA:GOC. 

Interpro

 IPR025814; DIM1.
 IPR020596; rRNA_Ade_Mease_Trfase_CS.
 IPR001737; rRNA_Ade_methylase_transferase.
 IPR020598; rRNA_Ade_methylase_Trfase_N.
 IPR011530; rRNA_adenine_dimethylase. 

Pfam

 PF00398; RrnaAD 

SMART

 SM00650; rADc 

PROSITE

 PS01131; RRNA_A_DIMETH 

PRINTS