| Tag | Content |
|---|
| CPLM ID | CPLM-007175 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Spindle pole component SPC72 |
Protein Synonyms/Alias | |
Gene Name | SPC72 |
Gene Synonyms/Alias | LDB4; SPI6; YAL047C; FUN42 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 590 | ISERERRKLDANASE | acetylation | [1] |
|
Reference | [1] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases. Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [ PMID: 23572591] |
Functional Description | Spindle pole body component that acts as the gamma- tubulin complex-binding protein of the SPB outer plaque. Anchors cytoplasmic microtubules at the at the half bridge of the spindle pole body (SPB) and accordingly functions in nuclear position and spindle orientation, including anaphase spindle migration into the bud. Recruits KIN4 kinase to both SPBs when cytoplasmic microtubules are defective. Links cytoplasmic microtubules with spindle orientation checkpoint (SPOC) components and, therefore, could function as part of the sensors of spindle orientation defects. Is strictly required for mating and karyogamy. |
Sequence Annotation | |
Keyword | Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Karyogamy; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 622 AA |
Protein Sequence | MVRRWIPSGR HLRNNDNTGD DDDSEFTNSM DSGMSIPSLR DSMTTRSSHN DPIKPALMND 60
SNKVKNLEKE LTNAKIKIQV LYEYIRRIPN KDGNAPSLGN DTDFRNSIIE GLNLEINKLK 120
QDLKAKEVEY QDTLQFVQEN LENSESIVNT INHLLSFILT HFNEQDENAH LLDKEERETL 180
EETLELSSDY VLEKMDTLSK FIIQFLQDFL HSKSRAESKQ DKEEFLSLAQ SSPAGSQLES 240
RDSPSSKEEN TDGGYQNDEI HDSNNHIDTE NVMANSTSLP ISAVESRFEK TLDTQLEIVI 300
ENLHKEYDQF INSIRLKFEK SQKLEKIIAS KLNEQSHLLD SLELEENSSS VIEKQDHLIS 360
QLKEKIESQS VLINNLEKLK EDIIKMKQNE KVLTKELETQ TKINKLKENN WDSYINDLEK 420
QINDLQIDKS EEFHVIQNQL DKLDLENYQL KNQLNTLDNQ KLILSQYESN FIKFNQNLLL 480
HLDSIFNILQ KILQESSIAQ FDRKMKSIKS VPNALKNLNL IQPKLESLYT FIETALESII 540
NSYISSLISM ETPEQPHQQG NELTATPNKE LTLRIEELQR RWISERERRK LDANASEARI 600
KALEQENESL RSKLFNLSIN NP 622 |
Gene Ontology | GO:0005824; C:outer plaque of spindle pole body; IDA:SGD. GO:0005200; F:structural constituent of cytoskeleton; IPI:SGD. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0000741; P:karyogamy; IEA:UniProtKB-KW. GO:0007020; P:microtubule nucleation; IMP:SGD. GO:0000070; P:mitotic sister chromatid segregation; IMP:SGD. GO:0000022; P:mitotic spindle elongation; IMP:SGD. GO:0031578; P:mitotic spindle orientation checkpoint; IPI:SGD. GO:0030473; P:nuclear migration along microtubule; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |