CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034777
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Lrp8 
Protein Synonyms/Alias
  
Gene Name
 Lrp8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
778FDNPVYRKTTEEEEEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; EGF-like domain; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 873 AA 
Protein Sequence
MGRPERGALR PLALLLLLLL LLLQLQHLST ADPLPGGQGP VKECEEDQFR CRNERCIPSV 60
WRCDEDNDCS DNSDEDDCPK RTCTDSDFTC DNGHCIPERW KCDGEEECPD GSDESKATCS 120
SEECPAEKLS CGPTSHKCVP ASWRCDGEKD CEGGADEAGC PTSAPGPCRE NDFQCGDGTC 180
ILAIKRCNQE RDCLDGSDEA GCLQESTCEG PRRFQCKSGE CVDGGKVCDD QRDCRDWSDE 240
PQKVCGLNEC LHNNGGCSHI CTDLKIGFEC TCPAGFQLLD QKTCGDIDEC QDPDACSQIC 300
VNYKGYFKCE CHPGYEMDTL TKNCKAVAGR SPSLIFTNRH EVRRIDLVKR DYSRLIPMLK 360
NVVALDVEVD TNRIYWCDLS YRKIYSAHMD KASIPDEQVV LIGEQLHSPE GLAVDWVHKH 420
IYWTDSGNKT VSVATTDGRR RCTLFNRDLS EPRAIAVDPL RGFMYWSDWG FQAKIEKAGL 480
NGADRQTLVS DNIEWPNGIT LDLLSQRLYW VDSKLHQLSS IDFNGGNRKM LIFSTDFLSH 540
PFGVAVFEDK VFWTDLENEA IFSANRLNGL EISILAENLN NPHDIVIFHE LKQPKAADAC 600
ELSAQPNGGC EYLCLPAPQI SSHSPKYTCA CPDTMWLGPD MKRCYRAPPS TSTTTLASAM 660
TRTVPATTGA PGTTIHDSTY QNHSTEMPSQ TAAVPHSVNI PKAHSTSPST LSPATSNHSQ 720
HYGNEGSQMG STVTAAVIGI IVPIVVIALL CMSGYLIWRN WKRKNTKSMN FDNPVYRKTT 780
EEEEEDELHI GRTAQIGHVY PAAISSYDRP LWAEPCLGET RDLEDPAPAH KELFVLPGEP 840
RSQLHQLPKN PLSELPVVKC KRVALSLEDD GLP 873 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:RGD.
 GO:0005875; C:microtubule associated complex; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0014069; C:postsynaptic density; IDA:RGD.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008035; F:high-density lipoprotein particle binding; IDA:RGD.
 GO:0071397; P:cellular response to cholesterol; IEP:RGD.
 GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.
 GO:0021987; P:cerebral cortex development; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR023415; LDLR_class-A_CS.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY 
PROSITE
 PS00010; ASX_HYDROXYL
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS