| Tag | Content |
|---|
| CPLM ID | CPLM-000124 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lysosomal alpha-mannosidase |
Protein Synonyms/Alias | Laman; Lysosomal acid alpha-mannosidase; Mannosidase alpha class 2B member 1; Mannosidase alpha-B; Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide |
Gene Name | MAN2B1 |
Gene Synonyms/Alias | LAMAN; MANB |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 334 | MWFKNLDKLIRLVNA | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages. |
Sequence Annotation | ACT_SITE 196 196 Nucleophile (By similarity).
METAL 72 72 Zinc (By similarity).
METAL 74 74 Zinc (By similarity).
METAL 196 196 Zinc (By similarity).
METAL 446 446 Zinc (By similarity).
CARBOHYD 133 133 N-linked (GlcNAc...) (Potential).
CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
CARBOHYD 367 367 N-linked (GlcNAc...).
CARBOHYD 497 497 N-linked (GlcNAc...) (Potential).
CARBOHYD 645 645 N-linked (GlcNAc...) (Potential).
CARBOHYD 651 651 N-linked (GlcNAc...) (Potential).
CARBOHYD 692 692 N-linked (GlcNAc...) (Potential).
CARBOHYD 766 766 N-linked (GlcNAc...).
CARBOHYD 832 832 N-linked (GlcNAc...) (Potential).
CARBOHYD 930 930 N-linked (GlcNAc...).
CARBOHYD 989 989 N-linked (GlcNAc...) (Potential).
DISULFID 55 358 By similarity.
DISULFID 268 273 By similarity.
DISULFID 412 472 By similarity.
DISULFID 493 501 By similarity. |
Keyword | Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Metal-binding; Polymorphism; Reference proteome; Signal; Zinc; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1011 AA |
Protein Sequence | MGAYARASGV CARGCLDSAG PWTMSRALRP PLPPLCFFLL LLAAAGARAG GYETCPTVQP 60
NMLNVHLLPH THDDVGWLKT VDQYFYGIKN DIQHAGVQYI LDSVISALLA DPTRRFIYVE 120
IAFFSRWWHQ QTNATQEVVR DLVRQGRLEF ANGGWVMNDE AATHYGAIVD QMTLGLRFLE 180
DTFGNDGRPR VAWHIDPFGH SREQASLFAQ MGFDGFFFGR LDYQDKWVRM QKLEMEQVWR 240
ASTSLKPPTA DLFTGVLPNG YNPPRNLCWD VLCVDQPLVE DPRSPEYNAK ELVDYFLNVA 300
TAQGRYYRTN HTVMTMGSDF QYENANMWFK NLDKLIRLVN AQQAKGSSVH VLYSTPACYL 360
WELNKANLTW SVKHDDFFPY ADGPHQFWTG YFSSRPALKR YERLSYNFLQ VCNQLEALVG 420
LAANVGPYGS GDSAPLNEAM AVLQHHDAVS GTSRQHVAND YARQLAAGWG PCEVLLSNAL 480
ARLRGFKDHF TFCQQLNISI CPLSQTAARF QVIVYNPLGR KVNWMVRLPV SEGVFVVKDP 540
NGRTVPSDVV IFPSSDSQAH PPELLFSASL PALGFSTYSV AQVPRWKPQA RAPQPIPRRS 600
WSPALTIENE HIRATFDPDT GLLMEIMNMN QQLLLPVRQT FFWYNASIGD NESDQASGAY 660
IFRPNQQKPL PVSRWAQIHL VKTPLVQEVH QNFSAWCSQV VRLYPGQRHL ELEWSVGPIP 720
VGDTWGKEVI SRFDTPLETK GRFYTDSNGR EILERRRDYR PTWKLNQTEP VAGNYYPVNT 780
RIYITDGNMQ LTVLTDRSQG GSSLRDGSLE LMVHRRLLKD DGRGVSEPLM ENGSGAWVRG 840
RHLVLLDTAQ AAAAGHRLLA EQEVLAPQVV LAPGGGAAYN LGAPPRTQFS GLRRDLPPSV 900
HLLTLASWGP EMVLLRLEHQ FAVGEDSGRN LSAPVTLNLR DLFSTFTITR LQETTLVANQ 960
LREAASRLKW TTNTGPTPHQ TPYQLDPANI TLEPMEIRTF LASVQWKEVD G 1011 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |