CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Enoyl-[acyl-carrier protein] reductase [NADPH, B-specific], mitochondrial 
Protein Synonyms/Alias
 Mitochondrial respiratory function protein 1; Trans-2-enoyl-CoA reductase 
Gene Name
 ETR1 
Gene Synonyms/Alias
 MRF1; MRF1'; YBR026C; YBR0310 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
45SVKNYTPKQDLSQSIacetylation[1]
218DNFDEVAKVLEDKYGacetylation[1]
238SESQNNDKTFAKEVLacetylation[1]
242NNDKTFAKEVLSKILacetylation[1]
247FAKEVLSKILGENARacetylation[1]
265ALNSVGGKSSASIARacetylation[1]
301PTSLHIFKGLTSKGYacetylation[1]
306IFKGLTSKGYWVTEKacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Required for respiration and the maintenance of the mitochondrial compartment. May have a role in the mitochondrial synthesis of fatty acids. 
Sequence Annotation
 MOD_RES 339 339 Phosphoserine.  
Keyword
 Complete proteome; Direct protein sequencing; DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Mitochondrion; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 380 AA 
Protein Sequence
MLPTFKRYMS SSAHQIPKHF KSLIYSTHEV EDCTKVLSVK NYTPKQDLSQ SIVLKTLAFP 60
INPSDINQLQ GVYPSRPEKT YDYSTDEPAA IAGNEGVFEV VSLPSGSSKG DLKLGDRVIP 120
LQANQGTWSN YRVFSSSSDL IKVNDLDLFS AATVSVNGCT GFQLVSDYID WNSNGNEWII 180
QNAGTSSVSK IVTQVAKAKG IKTLSVIRDR DNFDEVAKVL EDKYGATKVI SESQNNDKTF 240
AKEVLSKILG ENARVRLALN SVGGKSSASI ARKLENNALM LTYGGMSKQP VTLPTSLHIF 300
KGLTSKGYWV TEKNKKNPQS KIDTISDFIK MYNYGHIISP RDEIETLTWN TNTTTDEQLL 360
ELVKKGITGK GKKKMVVLEW 380 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0004319; F:enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; IEA:EC.
 GO:0016631; F:enoyl-[acyl-carrier-protein] reductase activity; IDA:SGD.
 GO:0019166; F:trans-2-enoyl-CoA reductase (NADPH) activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009060; P:aerobic respiration; IMP:SGD.
 GO:0006633; P:fatty acid biosynthetic process; IMP:SGD. 
Interpro
 IPR002085; ADH_SF_Zn-type.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
  
SMART
  
PROSITE
  
PRINTS