| Tag | Content |
|---|
| CPLM ID | CPLM-004847 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein suppressor of variegation 3-7 |
Protein Synonyms/Alias | |
Gene Name | Su(var)3-7 |
Gene Synonyms/Alias | Suvar(3)7; CG8599 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 839 | CDSRLPIKVFYLRQH | sumoylation | [1] |
|
Reference | [1] Sumoylation of Drosophila SU(VAR)3-7 is required for its heterochromatic function. Reo E, Seum C, Spierer P, Bontron S. Nucleic Acids Res. 2010 Jul;38(13):4254-62. [ PMID: 20299342] |
Functional Description | Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation. |
Sequence Annotation | DOMAIN 987 1026 BESS.
ZN_FING 217 236 C2H2-type 1.
ZN_FING 319 343 C2H2-type 2.
ZN_FING 425 446 C2H2-type 3.
ZN_FING 487 512 C2H2-type 4.
ZN_FING 605 629 C2H2-type 5.
ZN_FING 737 761 C2H2-type 6.
ZN_FING 829 852 C2H2-type 7.
MOD_RES 165 165 Phosphoserine.
MOD_RES 175 175 Phosphoserine.
MOD_RES 176 176 Phosphoserine.
MOD_RES 871 871 Phosphoserine.
MOD_RES 873 873 Phosphoserine.
MOD_RES 975 975 Phosphoserine. |
Keyword | Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1250 AA |
Protein Sequence | MDRDSSMQAK NLDAQCNPDL KMASANSETL ASATHELKIM DVEGGALVDP DHIEEVETSM 60
VIVVDDDDGD VAMVVEEDKH PMRDDPCIED IMDDEHAPLV AELQSALNNP DDKQASEDPL 120
LEDQEREPDA MSTKTEPSSD AESSHSYHDP MGLLERIEIH DPGDSQDDDD EDDESSNGGG 180
VDGGMRRKMP RAQRWLLWMK RWPWILHEDS DGTLAFCLYC NISINVNNRS RHIQQHNVSL 240
SHQERECNYL AFKKSEEETR GAISDNEIKH EFGTKSYVAA MKQKRISETE AFNNFNWLRW 300
LRWHPWLERS MPTGTIGTCR ICSVRMNVEF VYLRKRHETT KGHMEALRNL DSDKRSRKRK 360
RSKSNSVTNS GGDEAEREKE SEPEVGPEDA QDTPVVMMNG DVDSGDDPGK WCALIPDTNP 420
QQCRCTLCNC TMAITSFLRH CKTRAHCHML STPAEKGSSD IRGIWAVFAD MHPWLIADPE 480
DPSIGYCSVC RKRFMYGNSE IKRKNHEKSE KHTLALASAK AGIEVGSADG RGGDNMDEEE 540
AAASDQAQSS QTDDSEDNDD DNWSEIQKLG KGFAHKSSSE PRKATVRAGV RFYPWLCYSK 600
DRKTQICKFC RVRFHNEAAK ARHELSARHV KLVKQFKMRQ AKLHQGTNTQ TKHNAQDDEE 660
SQEQDEEYGE EEEDAEEDSQ SNFDLGTVQA RKTARADNKL FVKPIPATMK GKVMVWKGRF 720
PWLSYKKNEQ RGNYAWCKLC EVSLYLPSSK WASKHQRTSR HIRLRIDRKR NGGNPLKTSN 780
KNSGEISTVV ATASALASAE ARQKAAMAEL QAKYDWLDPD ANDENHCHCR VCDSRLPIKV 840
FYLRQHDASR KHVENKERQR ANAAAAANAP SVSPTSTVDA ERQESGMDKE SENDMSVRSD 900
GSTAEPLAKR SRRSMEVRRI IRALRDSMGK RQEERSQMDM ARDMICSSFD IVTRLRTLER 960
ESVAHNESMA QAPPSVTVSP IKPPEPRHVM DLFFDSISPT MKSLPPDLAA EGKSKIMQLV 1020
CSLELRAMQR NATTPTPATV SASSKWPSST TVTPVKTPPA PISAPLASVD ADLHSSVVTT 1080
PHEYNNGQNN NNDKETVPKE PVTGASSAQV TINGSAKDLP ENIRRILTSN QTQVTNRLET 1140
DSVRCVPLDK LTTQSRTNVN GRLSQGGTSE APSTPQADLS NGNTLAMIRQ IRVNNNNSSK 1200
ITVTNTPQMQ QPQQAQASIT SSTPIMRGGP SSNGCQITTF RTMVNHNRRP 1250 |
Gene Ontology | GO:0005721; C:centromeric heterochromatin; IDA:FlyBase. GO:0005634; C:nucleus; IDA:FlyBase. GO:0005701; C:polytene chromosome chromocenter; TAS:FlyBase. GO:0003682; F:chromatin binding; IDA:FlyBase. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0009048; P:dosage compensation by inactivation of X chromosome; IDA:FlyBase. GO:0090053; P:positive regulation of chromatin silencing at centromere; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |