UniProt Accession

 4EBP1_MOUSE; Q60876; Q3TDS8; Q9CZ40 

Genbank Protein ID

 U28656; AK013033; AK169979; AK170031; BC002045 

Genbank Nucleotide ID

 AAA88818.1; BAB28612.1; BAE41494.1; BAE41521.1; AAH02045.1 

Protein Name

 Eukaryotic translation initiation factor 4E-binding protein 1 

Protein Synonyms/Alias

 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I 

Gene Name

 Eif4ebp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
56	TRIIYDRKFLMECRN	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 36 36 Phosphothreonine; by MTOR (By
 MOD_RES 40 40 Phosphothreonine (By similarity).
 MOD_RES 45 45 Phosphothreonine; by MTOR (By
 MOD_RES 49 49 Phosphothreonine (By similarity).
 MOD_RES 53 53 Phosphotyrosine (By similarity).
 MOD_RES 64 64 Phosphoserine; by DYRK2, MAPK1, MAPK3 and
 MOD_RES 69 69 Phosphothreonine; by MTOR (By
 MOD_RES 82 82 Phosphoserine (By similarity).
 MOD_RES 100 100 Phosphoserine; by DYRK2 (By similarity).
 MOD_RES 111 111 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Phosphoprotein; Protein synthesis inhibitor; Reference proteome; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 117 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IC:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0030371; F:translation repressor activity; TAS:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0008286; P:insulin receptor signaling pathway; IDA:MGI.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0031333; P:negative regulation of protein complex assembly; IEA:Compara.
 GO:0045947; P:negative regulation of translational initiation; IDA:MGI.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0031929; P:TOR signaling cascade; IEA:Compara. 

Interpro

 IPR008606; EIF4EBP. 

Pfam

 PF05456; eIF_4EBP 

SMART

  

PROSITE

  

PRINTS