CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022001
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uncharacterized protein C12orf4 
Protein Synonyms/Alias
  
Gene Name
 C12orf4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
33LELRVPLKFPVQENAubiquitination[1]
176RQGIEMEKVMQELGKacetylation[2]
183KVMQELGKSLTDQDVubiquitination[3]
207SQQDLENKWSNELKQubiquitination[1, 3]
213NKWSNELKQSTAIQKubiquitination[3]
220KQSTAIQKQEYQEWVubiquitination[1, 3, 4, 5]
235IKLHQDLKNPNNSSLubiquitination[1]
247SSLSEEIKVQPSQFRubiquitination[1, 3]
343INSYSGIKRDFATVCubiquitination[3]
384TQRRSKLKESLDSGNubiquitination[1, 3]
496RRAELVFKCVKGFMMubiquitination[1]
551STLTLTSKH******ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 MOD_RES 241 241 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 552 AA 
Protein Sequence
MKKNRERFCN REREFVYKFK VGSQCLELRV PLKFPVQENA SHLHGRLMLL HSLPCFIEKD 60
LKEALTQFIE EESLSDYDRD AEASLAAVKS GEVDLHQLAS TWAKAYAETT LEHARPEEPS 120
WDEDFADVYH DLIHSPASET LLNLEHNYFV SISELIGERD VELKKLRERQ GIEMEKVMQE 180
LGKSLTDQDV NSLAAQHFES QQDLENKWSN ELKQSTAIQK QEYQEWVIKL HQDLKNPNNS 240
SLSEEIKVQP SQFRESVEAI GRIYEEQRKL EESFTIHLGA QLKTMHNLRL LRADMLDFCK 300
HKRNHRSGVK LHRLQTALSL YSTSLCGLVL LVDNRINSYS GIKRDFATVC QECTDFHFPR 360
IEEQLEVVQQ VVLYARTQRR SKLKESLDSG NQNGGNDDKT KNAERNYLNV LPGEFYITRH 420
SNLSEIHVAF HLCVDDHVKS GNITARDPAI MGLRNILKVC CTHDITTISI PLLLVHDMSE 480
EMTIPWCLRR AELVFKCVKG FMMEMASWDG GISRTVQFLV PQSISEEMFY QLSNMLPQIF 540
RVSSTLTLTS KH 552 
Gene Ontology
  
Interpro
 IPR019311; DUF2362. 
Pfam
 PF10154; DUF2362 
SMART
  
PROSITE
  
PRINTS