CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045549
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytosolic 10-formyltetrahydrofolate dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Aldh1l1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
35GVFTIPDKDGKADPLacetylation[1]
38TIPDKDGKADPLGLEacetylation[1]
48PLGLEAEKDGVPVFKacetylation[1]
55KDGVPVFKFPRWRARacetylation[1]
229NWIRGNDKVPGAWTEacetylation[1]
615KFAELTLKAGIPKGVacetylation[1]
645SDHPDVRKIGFTGSTacetylation[1]
656TGSTEVGKHIMKSCAacetylation[1]
845VFTRDINKALYVSDKacetylation[1]
865VFINTYNKTDVAAPFacetylation[1]
876AAPFGGFKQSGFGKDacetylation[1]
882FKQSGFGKDLGEAALacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 902 AA 
Protein Sequence
MKIAVIGQSL FGQEVYCQLR KEGHEVVGVF TIPDKDGKAD PLGLEAEKDG VPVFKFPRWR 60
ARGQALPEVV AKYQALGAEL NVLPFCSQFI PMEVINAPRH GSIIYHPSLL PRHRGASAIN 120
WTLIHGDKKG GFTIFWADDG LDTGDLLLQK ECEVLPDDTV STLYNRFLFP EGIKGMVQAV 180
RLIAEGTAPR CPQSEEGATY EGIQKKETAK INWDQPAEAI HNWIRGNDKV PGAWTEACGQ 240
KLTFFNSTLN TSGLSTQGEA LPIPGAHRPG VVTKAGLILF GNDDRMLLVK NIQLEDGKMM 300
PASQFFKGSA SSDLELTEAE LATAEAVRSS WMRILPNVPE VEDSTDFFKS GAASVDVVRL 360
VEEVKELCDG LELENEDVYM ATTFRGFIQL LVRKLRGEDD ESECVINYVE KAVNKLTLQM 420
PYQLFIGGEF VDAEGSKTYN TINPTDGSVS RTVARGLCLG VCVLTADMQG HGRGIEQEDE 480
ERGERGQLLA RLADVMEQHQ EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI 540
QGATIPINQA RPNRNLTLTK KEPVGVCGIV IPWNYPLMML SWKTAACLAA GNTVVIKPAQ 600
VTPLTALKFA ELTLKAGIPK GVVNILPGSG SLVGQRLSDH PDVRKIGFTG STEVGKHIMK 660
SCALSNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF FNKGENCIAA GRLFVEESIH 720
NQFVQKVESE LEGQAAGGAM VPSEEWLGKN RKAETRMNRV LCEPVPSQAY ASNVHQSTVS 780
PAGFFFQPTV FTDVEDHMYI AKEESFGPIM IISRFADGDV DAVLSRANAT EFGLASGVFT 840
RDINKALYVS DKLQAGTVFI NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRIKTVTF 900
EY 902 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; IEA:InterPro.
 GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.
 GO:0008168; F:methyltransferase activity; IEA:InterPro.
 GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0009258; P:10-formyltetrahydrofolate catabolic process; IEA:InterPro.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0032259; P:methylation; IEA:GOC.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro. 
Interpro
 IPR011407; 10_FTHF_DH.
 IPR009081; Acyl_carrier_prot-like.
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR005793; Formyl_trans_C.
 IPR002376; Formyl_transf_N.
 IPR011034; Formyl_transferase_C-like.
 IPR001555; GART_AS. 
Pfam
 PF00171; Aldedh
 PF02911; Formyl_trans_C
 PF00551; Formyl_trans_N
 PF00550; PP-binding 
SMART
  
PROSITE
 PS50075; ACP_DOMAIN
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU
 PS00373; GART 
PRINTS