UniProt Accession

 VPS29_RAT; B2RZ78; A6J1A4 

Genbank Protein ID

 CH473973; BC167055 

Genbank Nucleotide ID

 EDM13693.1; AAI67055.1 

Protein Name

 Vacuolar protein sorting-associated protein 29 

Protein Synonyms/Alias

 Vesicle protein sorting 29 

Gene Name

 Vps29 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
50	KESYDYLKTLAGDVH	acetylation	[1]
73	SLNYPEQKVVTVGQF	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). 

Sequence Annotation

 METAL 8 8 Zinc 1 (By similarity).
 METAL 10 10 Zinc 1 (By similarity).
 METAL 39 39 Zinc 1 (By similarity).
 METAL 39 39 Zinc 2 (By similarity).
 METAL 62 62 Zinc 2 (By similarity).
 METAL 86 86 Zinc 2 (By similarity).
 METAL 115 115 Zinc 2 (By similarity).
 METAL 117 117 Zinc 1 (By similarity).
 MOD_RES 50 50 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Endosome; Hydrolase; Membrane; Metal-binding; Protein transport; Reference proteome; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004647; F:phosphoserine phosphatase activity; IEA:EC.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR024654; Calcineurin-like_PEstase_dom.
 IPR000979; Phosphodiesterase_MJ0936. 

Pfam

 PF12850; Metallophos_2 

SMART

  

PROSITE

  

PRINTS