CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005531
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 1-acyl-sn-glycerol-3-phosphate acyltransferase 
Protein Synonyms/Alias
 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase 
Gene Name
 plsC 
Gene Synonyms/Alias
 parF; b3018; JW2986 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
136AEVVNHFKKRRISIWacetylation[1]
211IDVSQYGKDQVRELAacetylation[1]
234QKIAELDKEVAEREAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor. 
Sequence Annotation
 MOTIF 73 78 HXXXXD motif.
 MOD_RES 1 1 N-formylmethionine (Probable).  
Keyword
 Acyltransferase; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Formylation; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 245 AA 
Protein Sequence
MLYIFRLIIT VIYSILVCVF GSIYCLFSPR NPKHVATFGH MFGRLAPLFG LKVECRKPTD 60
AESYGNAIYI ANHQNNYDMV TASNIVQPPT VTVGKKSLLW IPFFGQLYWL TGNLLIDRNN 120
RTKAHGTIAE VVNHFKKRRI SIWMFPEGTR SRGRGLLPFK TGAFHAAIAA GVPIIPVCVS 180
TTSNKINLNR LHNGLVIVEM LPPIDVSQYG KDQVRELAAH CRSIMEQKIA ELDKEVAERE 240
AAGKV 245 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; IEA:EC.
 GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR004552; AGP_acyltrans.
 IPR002123; Plipid/glycerol_acylTrfase. 
Pfam
 PF01553; Acyltransferase 
SMART
 SM00563; PlsC 
PROSITE
  
PRINTS