CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037554
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Breast cancer type 2 susceptibility protein 
Protein Synonyms/Alias
  
Gene Name
 BRCA2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
118SNHDESLKKNDRFIAubiquitination[1]
119NHDESLKKNDRFIASubiquitination[1]
145AASHGFGKTSGNSFKubiquitination[2]
220ANADECEKSKNQVKEubiquitination[2]
313LDTENKRKKDFLTSEubiquitination[2]
334SSLPKSEKPLNEETVubiquitination[1, 2]
478IHDETSYKGKK****ubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 481 AA 
Protein Sequence
MDQADDVSCP LLNSCLSESP VVLQCTHVTP QRDKSVVCGS LFHTPKFVKG RQTPKHISES 60
LGAEVDPDMS WSSSLATPPT LSSTVLIVRN EEASETVFPH DTTANVKSYF SNHDESLKKN 120
DRFIASVTDS ENTNQREAAS HGFGKTSGNS FKVNSCKDHI GKSMPNVLED EVYETVVDTS 180
EEDSFSLCFS KCRTKNLQKV RTSKTRKKIF HEANADECEK SKNQVKEKYS FVSEVEPNDT 240
DPLDSNVANQ KPFESGSDKI SKEVVPSLAC EWSQLTLSGL NGAQMEKIPL LHISSCDQNI 300
SEKDLLDTEN KRKKDFLTSE NSLPRISSLP KSEKPLNEET VVNKRDEEQH LESHTDCILA 360
VKQAISGTSP VASSFQGIKK SIFRIRESPK ETFNASFSGH MTDPNFKKET EASESGLEIH 420
TVCSQKEDSL CPNLIDNGSW PATTTQNSVA LKNAGLISTL KKKTNKFIYA IHDETSYKGK 480
K 481 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0051276; P:chromosome organization; IEA:Compara.
 GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Compara.
 GO:0000724; P:double-strand break repair via homologous recombination; IEA:Compara.
 GO:0008585; P:female gonad development; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0001833; P:inner cell mass cell proliferation; IEA:Compara.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Compara.
 GO:0007141; P:male meiosis I; IEA:Compara.
 GO:0001556; P:oocyte maturation; IEA:Compara.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0032465; P:regulation of cytokinesis; IEA:Compara.
 GO:0048478; P:replication fork protection; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IEA:Compara.
 GO:0010225; P:response to UV-C; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR015525; BRCA2. 
Pfam
  
SMART
  
PROSITE
  
PRINTS