CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034273
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Chromobox protein homolog 3 
Protein Synonyms/Alias
  
Gene Name
 Cbx3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
5***MASNKTTLQKMGacetylation[1]
5***MASNKTTLQKMGsuccinylation[1]
21KQNGKSKKVEEAEPEacetylation[1, 2]
21KQNGKSKKVEEAEPEsuccinylation[1]
34PEEFVVEKVLDRRVVacetylation[2]
34PEEFVVEKVLDRRVVubiquitination[3]
44DRRVVNGKVEYFLKWacetylation[1, 2, 4, 5]
50GKVEYFLKWKGFTELacetylation[1]
50GKVEYFLKWKGFTELsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 71 AA 
Protein Sequence
MASNKTTLQK MGKKQNGKSK KVEEAEPEEF VVEKVLDRRV VNGKVEYFLK WKGFTELTNQ 60
GALPEVSTLN E 71 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW. 
Interpro
 IPR023780; Chromo_domain.
 IPR000953; Chromo_domain/shadow.
 IPR016197; Chromodomain-like. 
Pfam
 PF00385; Chromo 
SMART
 SM00298; CHROMO 
PROSITE
 PS50013; CHROMO_2 
PRINTS