CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021595
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Potassium channel subfamily K member 13 
Protein Synonyms/Alias
 Tandem pore domain halothane-inhibited potassium channel 1; THIK-1 
Gene Name
 KCNK13 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
350SGEMISMKDLLAANKacetylation[1]
Reference
 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 
Functional Description
 Potassium channel displaying weak inward rectification in symmetrical K(+) solution (By similarity). 
Sequence Annotation
 CARBOHYD 59 59 N-linked (GlcNAc...) (Potential).
 CARBOHYD 65 65 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 408 AA 
Protein Sequence
MAGRGFSWGP GHLNEDNARF LLLAALIVLY LLGGAAVFSA LELAHERQAK QRWEERLANF 60
SRGHNLSRDE LRGFLRHYEE ATRAGIRVDN VRPRWDFTGA FYFVGTVVST IGFGMTTPAT 120
VGGKIFLIFY GLVGCSSTIL FFNLFLERLI TIIAYIMKSC HQRQLRRRGA LPQESLKDAG 180
QCEVDSLAGW KPSVYYVMLI LCTASILISC CASAMYTPIE GWSYFDSLYF CFVAFSTIGF 240
GDLVSSQNAH YESQGLYRFA NFVFILMGVC CIYSLFNVIS ILIKQSLNWI LRKMDSGCCP 300
QCQRGLLRSR RNVVMPGSVR NRCNISIETD GVAESDTDGR RLSGEMISMK DLLAANKASL 360
AILQKQLSEM ANGCPHQTST LARDNEFSGG VGAFAIMNNR LAETSGDR 408 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005267; F:potassium channel activity; TAS:Reactome.
 GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 
Interpro
 IPR003280; 2pore_dom_K_chnl.
 IPR005410; 2pore_dom_K_chnl_THIK.
 IPR013099; Ion_trans_2. 
Pfam
 PF07885; Ion_trans_2 
SMART
  
PROSITE
  
PRINTS
 PR01333; 2POREKCHANEL.
 PR01588; THIKCHANNEL.