CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014227
UniProt Accession
Genbank Protein ID
 M27008 
Genbank Nucleotide ID
Protein Name
 Alpha-1-acid glycoprotein 1 
Protein Synonyms/Alias
 AGP 1; Orosomucoid-1; OMD 1 
Gene Name
 Orm1 
Gene Synonyms/Alias
 Agp1; Orm-1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
148RGLSLYAKRPDITPEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction. 
Sequence Annotation
 MOD_RES 19 19 Pyrrolidone carboxylic acid (By
 CARBOHYD 25 25 N-linked (GlcNAc...).
 CARBOHYD 34 34 N-linked (GlcNAc...).
 CARBOHYD 76 76 N-linked (GlcNAc...).
 CARBOHYD 94 94 N-linked (GlcNAc...).
 CARBOHYD 104 104 N-linked (GlcNAc...).
 DISULFID 91 184 By similarity.  
Keyword
 Acute phase; Complete proteome; Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 207 AA 
Protein Sequence
MALHTVLIIL SLLPMLEAQN PEHANFTIGE PITNETLSWL SDKWFFMGAA FRKLEYRQAI 60
QTMQSEFFYL TTNLINDTIE LRESQTIGDQ CVYNSTHLGF QRENGTFSKY EGGVETFAHL 120
IVLRKHGAFM LAFDLKDEKK RGLSLYAKRP DITPELREVF QKAVTHVGMD ESEIIFVDWK 180
KDRCGQQEKK QLELGKETKK DPEEGQA 207 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:InterPro.
 GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
 GO:0002682; P:regulation of immune system process; IEA:InterPro.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR001500; A1A_glycop.
 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR000566; Lipocln_cytosolic_FA-bd_dom. 
Pfam
 PF00061; Lipocalin 
SMART
  
PROSITE
 PS00213; LIPOCALIN 
PRINTS
 PR00708; A1AGLPROTEIN.