CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023752
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable U3 small nucleolar RNA-associated protein 11 
Protein Synonyms/Alias
 U3 snoRNA-associated protein 11; UTP11-like protein 
Gene Name
 UTP11L 
Gene Synonyms/Alias
 CGI-94; HDCMB12P 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26RSQPGFRKHLGLLEKubiquitination[1]
33KHLGLLEKKKDYKLRubiquitination[1]
34HLGLLEKKKDYKLRAubiquitination[1]
35LGLLEKKKDYKLRADubiquitination[1]
61LRKKALEKNPDEFYYubiquitination[1]
74YYKMTRVKLQDGVHIubiquitination[1]
86VHIIKETKEEVTPEQubiquitination[1]
95EVTPEQLKLMRTQDVubiquitination[1]
103LMRTQDVKYIEMKRVubiquitination[1]
120AKKIERLKSELHLLDubiquitination[1, 2, 3]
131HLLDFQGKQQNKHVFubiquitination[1, 4]
135FQGKQQNKHVFFFDTubiquitination[1]
144VFFFDTKKEVEQFDVubiquitination[1]
176PRIETLQKEKVKGVTubiquitination[1]
178IETLQKEKVKGVTNQubiquitination[1]
180TLQKEKVKGVTNQTGubiquitination[1, 5]
189VTNQTGLKRIAKERQubiquitination[1]
197RIAKERQKQYNCLTQubiquitination[1]
218KLFVIAQKIQTRKDLubiquitination[1]
228TRKDLMDKTQKVKVKubiquitination[1]
231DLMDKTQKVKVKKETubiquitination[1]
246VNSPAIYKFQSRRKRubiquitination[1, 2, 3, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity). 
Sequence Annotation
 MOD_RES 241 241 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 253 AA 
Protein Sequence
MAAAFRKAAK SRQREHRERS QPGFRKHLGL LEKKKDYKLR ADDYRKKQEY LKALRKKALE 60
KNPDEFYYKM TRVKLQDGVH IIKETKEEVT PEQLKLMRTQ DVKYIEMKRV AEAKKIERLK 120
SELHLLDFQG KQQNKHVFFF DTKKEVEQFD VATHLQTAPE LVDRVFNRPR IETLQKEKVK 180
GVTNQTGLKR IAKERQKQYN CLTQRIEREK KLFVIAQKIQ TRKDLMDKTQ KVKVKKETVN 240
SPAIYKFQSR RKR 253 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HGNC.
 GO:0005615; C:extracellular space; IDA:HGNC.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HGNC.
 GO:0032040; C:small-subunit processome; IEA:InterPro.
 GO:0006917; P:induction of apoptosis; IMP:HGNC.
 GO:0007399; P:nervous system development; IMP:HGNC.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; IMP:HGNC.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR007144; SSU_processome_Utp11. 
Pfam
 PF03998; Utp11 
SMART
  
PROSITE
  
PRINTS