CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038881
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calcium/calmodulin-dependent protein kinase type II subunit beta 
Protein Synonyms/Alias
  
Gene Name
 Camk2b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
69ARICRLLKHSNIVRLacetylation[1]
268ITAHEALKHPWVCQRacetylation[1]
292QETVECLKKFNARRKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 589 AA 
Protein Sequence
MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 60
EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 120
LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 180
LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 240
VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 300
KGAILTTMLA TRNFSAAKSL LNKKADGVKP QTNSTKNSSA ITSPKGSLPP AALESSDSTN 360
TTIEDEDAKA PRISDILNSV RRGCGTPEAE GPLSVGPPPC LSPGLLGPLP TPSPRISDIL 420
NSVRRGSGTP EAEGLPPVGP PPCPSPTLPG PLPTPSRKQE IIKTTEQLIE AVNNGDFEAY 480
AKICDPGLTS FEPEALGNLV EGMDFHRFYF ENLLAKNSKP IHTTILNPHV HVIGEDAACI 540
AYIRLTQYID GQGRPRTSQS EETRVWHRRD GKWQNVHFHC SGAPVAPLQ 589 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0051233; C:spindle midzone; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:Compara.
 GO:0060466; P:activation of meiosis involved in egg activation; IEA:Compara.
 GO:0006816; P:calcium ion transport; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0002030; P:inhibitory G-protein coupled receptor phosphorylation; IEA:Compara.
 GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0032222; P:regulation of synaptic transmission, cholinergic; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEA:Compara. 
Interpro
 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR013543; Ca/CaM-dep_prot_kinase-assoc.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF08332; CaMKII_AD
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS