CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039102
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein RGD1564788 
Protein Synonyms/Alias
  
Gene Name
 Wrn 
Gene Synonyms/Alias
 RGD1564788 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1234TYALFQEKKMSLHSIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1400 AA 
Protein Sequence
METTSLRRKF PEWMSTQNKS CATQEKASIQ KSVLEDDLPF LEFTGSVVYS YEASDCSFLS 60
EDISMHLSDG DVVGFDMEWP PIYKQGKRSR VAVIQLCVSE SKCYLFHISS MSVFPQGLKM 120
LLENKSIRKA GVGIEGDQWK LLRDFDVKLE SFVELTDVAN RKLKCAETWS LNGLVKHVLG 180
KQLLKDKSIR CSNWSDFPLS EDQKLYAATD AYAGLIIYQK LENLGDAVQV FALNKAEESL 240
PMEMKKQLNS ISEEMRDLAN HFPVTCRNLE TLQRVPMILE NISENLCSLR KVICASTDTG 300
TKLEPGGGSH LLSSEGSAAV GEKEKQMGEH RTFPKIKEEA WDPELDSLVK HEAVDVFRKQ 360
VKQEKGGFED EMEDSLLREV MERTCLMPSI SEYDLQDLEQ QAKEEKHNAI SHQFSEHLSP 420
DDDEKDSSYI IESDEDLEME MLKSLENLNS DVGEPTHSKW LETGGSVNLP PEEEDGDGKE 480
AFEEEQEEED HLLPEPNAKQ INCLKTYFGH CSFKPVQWKV IHSVLEERRD NVVVMATGYG 540
KSLCFQYPPV YTGKIGIVIS PLISLMEDQV LQLEMSNIPA CLLGSAQPKN ILGDIKLGRY 600
RIIYITPEFC SGNLDLLQQL DSNIGITLIA VDEAHCISEW GHDFRSSFRT LGSLKTALPL 660
VPVIALSATA SSSIREDIIR CLNLKDPHIT CTGFDRPNLY LEVERKTGNI LQDLKPFLVR 720
KTSSAWEFEG PTIIYCPSRK VTEQVTVELG KLNVACQAYH AGMKISERKD IHHRFLRDEI 780
QCVVATIAFG MGINKADIRK VIHYGAPKEM ESYYQEIGRA GRDGLQSSCH LLWAPADFNT 840
SRNRLIEIHN EKFRLHKLKM MVKMEKYLHS SRCRRQIILS HFEDKRLQKA SLAVMGTEKC 900
CDNCRPRLNH CSSANNSEDT AQDFGPQAFQ LLSAVDILQE KFGIKIPILF LRGSNSQRLP 960
EKYHNHRLFG AGKEQAESWW KALSHHLIAE GFLVEVPKQN KFIKTCSLTK KGRKWLGEAI 1020
LQSPPSLVLQ ADEEAFSRKA LLSSSNPVSS ETKPHSSNQK PTGSSTQQSN LEGAYSDKVP 1080
EKFSSGSNIP KKSVVMQSPG TSYSSWEPVI SAQEVDTRTV LYARLVEARQ KHANEVDVPP 1140
AVLATNKVLL DMAKMRPTTV ENVKQIDGVS EGKAALLAPL TEVIKHFCQV NSVQTDLFAS 1200
TKPQEDEEKS QEMENKACSL PQSAAVTYAL FQEKKMSLHS IAENRLLPLT AVGMHLAQAV 1260
KAGHPLDMER AGLTPETRKI IMDVIRNPPI NSDMYKVKLI RMLVPENIDT YLIHMMIEIL 1320
ESGSHGRTQP SCDSNRKRCL PSPAESCGSF KKSKEMVTET KAPSEMSQRK LPEWFVKGNV 1380
PLAATGSSSM AKTKKKGLFS 1400 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006310; P:DNA recombination; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:InterPro. 
Interpro
 IPR002562; 3'-5'_exonuclease_dom.
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR004589; DNA_helicase_ATP-dep_RecQ.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR010997; HRDC-like.
 IPR002121; HRDC_dom.
 IPR027417; P-loop_NTPase.
 IPR012337; RNaseH-like_dom.
 IPR018982; RQC_domain.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00270; DEAD
 PF01612; DNA_pol_A_exo1
 PF00271; Helicase_C
 PF00570; HRDC
 PF09382; RQC 
SMART
 SM00474; 35EXOc
 SM00487; DEXDc
 SM00490; HELICc
 SM00341; HRDC
 SM00956; RQC 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS50967; HRDC 
PRINTS