CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016051
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase KCMF1 
Protein Synonyms/Alias
 Differentially expressed in branching tubulogenesis 91; Debt-91 
Gene Name
 Kcmf1 
Gene Synonyms/Alias
 Debt91 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
14VSCDACLKGNFRGRRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination (By similarity). 
Sequence Annotation
 ZN_FING 3 50 ZZ-type.
 ZN_FING 78 101 C2H2-type.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 212 212 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Ligase; Metal-binding; Phosphoprotein; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 381 AA 
Protein Sequence
MSRHEGVSCD ACLKGNFRGR RYKCLICYDY DLCASCYESG ATTTRHTTDH PMQCILTRVD 60
FDLYYGGEAF SVEQPQSFTC PYCGKMGYTE TSLQEHVTSE HAETSTEVIC PICAALPGGD 120
PNHVTDDFAA HLTLEHRAPR DLDESSGVRH VRRMFHPGRG LGGPRARRSN MHFTSSSTGG 180
LSSSQSSYSP SSREAMDPIA ELLSQLSGVR RSAGGQLNSS GPSASQLQQL QMQLQLERQH 240
AQAARQQLET ARNASRRTNT SSVTTTITQA TATANTANTE NSPQALHNSQ FLLTRLNDPK 300
MSEAERQSME SERADRSLFV QELLLSTLVR EESSSSDEDD RGEMADFGAM GCVDIMPLDV 360
ALENLNLKES NKGNEPPPPP L 381 
Gene Ontology
 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR008598; Di19_RING_finger_144.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR000433; Znf_ZZ. 
Pfam
 PF05605; Di19
 PF00569; ZZ 
SMART
 SM00355; ZnF_C2H2
 SM00291; ZnF_ZZ 
PROSITE
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS