CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013212
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alcohol dehydrogenase YqhD 
Protein Synonyms/Alias
  
Gene Name
 yqhD 
Gene Synonyms/Alias
 b3011; JW2978 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
16PTRILFGKGAIAGLRacetylation[1]
42TYGGGSVKKTGVLDQacetylation[1]
43YGGGSVKKTGVLDQVpupylation[2]
125HILQTGGKEIKSAIPacetylation[1]
160SRKTTGDKQAFHSAHacetylation[1]
206TVEQYVTKPVDAKIQacetylation[1]
233EDGPKALKEPENYDVacetylation[1]
358SSIPALLKKLEEHGMacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222] 
Functional Description
 NADP-dependent ADH activity. 
Sequence Annotation
 NP_BIND 38 40 NADP.
 NP_BIND 93 99 NADP.
 NP_BIND 179 182 NADP.
 METAL 194 194 Zinc; catalytic.
 METAL 198 198 Zinc; catalytic.
 METAL 267 267 Zinc; catalytic.
 METAL 281 281 Zinc; catalytic.
 BINDING 138 138 NADP.
 BINDING 147 147 NADP.
 BINDING 160 160 NADP.  
Keyword
 3D-structure; Complete proteome; Metal-binding; NADP; Oxidoreductase; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 387 AA 
Protein Sequence
MNNFNLHTPT RILFGKGAIA GLREQIPHDA RVLITYGGGS VKKTGVLDQV LDALKGMDVL 60
EFGGIEPNPA YETLMNAVKL VREQKVTFLL AVGGGSVLDG TKFIAAAANY PENIDPWHIL 120
QTGGKEIKSA IPMGCVLTLP ATGSESNAGA VISRKTTGDK QAFHSAHVQP VFAVLDPVYT 180
YTLPPRQVAN GVVDAFVHTV EQYVTKPVDA KIQDRFAEGI LLTLIEDGPK ALKEPENYDV 240
RANVMWAATQ ALNGLIGAGV PQDWATHMLG HELTAMHGLD HAQTLAIVLP ALWNEKRDTK 300
RAKLLQYAER VWNITEGSDD ERIDAAIAAT RNFFEQLGVP THLSDYGLDG SSIPALLKKL 360
EEHGMTQLGE NHDITLDVSR RIYEAAR 387 
Gene Ontology
 GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IDA:EcoCyc.
 GO:0004024; F:alcohol dehydrogenase activity, zinc-dependent; IDA:EcoCyc.
 GO:0033721; F:aldehyde dehydrogenase (NADP+) activity; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc.
 GO:0051143; P:propanediol metabolic process; NAS:EcoliWiki.
 GO:0000302; P:response to reactive oxygen species; IMP:EcoCyc. 
Interpro
 IPR001670; ADH_Fe.
 IPR018211; ADH_Fe_CS. 
Pfam
 PF00465; Fe-ADH 
SMART
  
PROSITE
 PS00913; ADH_IRON_1
 PS00060; ADH_IRON_2 
PRINTS