CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001572
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myelin protein zero-like protein 1 
Protein Synonyms/Alias
 Protein zero-related 
Gene Name
 MPZL1 
Gene Synonyms/Alias
 PZR; UNQ849/PRO1787 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
212SESLSPVKQAPRKSPubiquitination[1]
227SDTEGLVKSLPSGSHubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. 
Sequence Annotation
 DOMAIN 36 146 Ig-like V-type.
 MOTIF 239 244 ITIM motif 1.
 MOTIF 261 266 ITIM motif 2.
 MOD_RES 208 208 Phosphoserine.
 MOD_RES 210 210 Phosphoserine.
 MOD_RES 219 219 Phosphoserine.
 MOD_RES 221 221 Phosphoserine.
 MOD_RES 241 241 Phosphotyrosine.
 MOD_RES 260 260 Phosphoserine.
 MOD_RES 263 263 Phosphotyrosine.
 CARBOHYD 50 50 N-linked (GlcNAc...).
 CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
 DISULFID 58 135 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 269 AA 
Protein Sequence
MAASAGAGAV IAAPDSRRWL WSVLAAALGL LTAGVSALEV YPKEIFVANG TQGKLTCKFK 60
STSTTGGLTS VSWSFQPEGA DTTVSFFHYS QGQVYLGNYP PFKDRISWAG DLDKKDASIN 120
IENMQFIHNG TYICDVKNPP DIVVQPGHIR LYVVEKENLP VFPVWVVVGI VTAVVLGLTL 180
LISMILAVLY RRKNSKRDYT GCSTSESLSP VKQAPRKSPS DTEGLVKSLP SGSHQGPVIY 240
AQLDHSGGHH SDKINKSESV VYADIRKN 268 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005198; F:structural molecule activity; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013106; Ig_V-set.
 IPR003596; Ig_V-set_subgr.
 IPR000920; Myelin_P0. 
Pfam
 PF07686; V-set 
SMART
 SM00406; IGv 
PROSITE
 PS50835; IG_LIKE 
PRINTS
 PR00213; MYELINP0.