UniProt Accession

 VDAC1_YEAST; P04840; D6W1C3 

Genbank Protein ID

 X02324; M34907; U12141; Z71331; BK006947 

Genbank Nucleotide ID

 CAA26184.1; AAA35208.1; AAA99656.1; CAA95926.1; DAA10489.1 

Protein Name

 Mitochondrial outer membrane protein porin 1 

Protein Synonyms/Alias

 Voltage-dependent anion-selective channel protein 1; VDAC-1 

Gene Name

 POR1 

Gene Synonyms/Alias

 OMP2; VDAC1; YNL055C; N2441; YNL2441C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
50	LKAKQPVKDGPLSTN	ubiquitination	[1]
61	LSTNVEAKLNDKQTG	acetylation	[2]
65	VEAKLNDKQTGLGLT	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Is the major permeability fator of the mitochondrial outer membrane. 

Sequence Annotation

 MOD_RES 109 109 Phosphoserine.
 MOD_RES 117 117 Phosphothreonine.  

Keyword

 Complete proteome; Direct protein sequencing; Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Porin; Reference proteome; Transmembrane; Transmembrane beta strand; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0031307; C:integral to mitochondrial outer membrane; IDA:SGD.
 GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome.
 GO:0046930; C:pore complex; IEA:UniProtKB-KW.
 GO:0015288; F:porin activity; IEA:UniProtKB-KW.
 GO:0008308; F:voltage-gated anion channel activity; IDA:SGD.
 GO:0006915; P:apoptotic process; IMP:SGD.
 GO:0045454; P:cell redox homeostasis; IMP:SGD.
 GO:0051027; P:DNA transport; IMP:SGD.
 GO:0007005; P:mitochondrion organization; IMP:SGD. 

Interpro

 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 

Pfam

 PF01459; Porin_3 

SMART

  

PROSITE

 PS00558; EUKARYOTIC_PORIN 

PRINTS

 PR00185; EUKARYTPORIN.