UniProt Accession

 M0R0C3_HUMAN; M0R0C3 

Genbank Protein ID

 AC011500 

Genbank Nucleotide ID

  

Protein Name

 Mitochondrial import inner membrane translocase subunit TIM50 

Protein Synonyms/Alias

  

Gene Name

 TIMM50 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	DDPLAAFKQRQSRLE	ubiquitination	[1, 2, 3, 4]
82	QRLAELSKSNKQNLF	ubiquitination	[2, 3]
85	AELSKSNKQNLFLGS	ubiquitination	[1, 2, 3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 104 AA 

Protein Sequence

Gene Ontology

 GO:0005744; C:mitochondrial inner membrane presequence translocase complex; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:InterPro. 

Interpro

 IPR023214; HAD-like_dom.
 IPR004274; NIF.
 IPR027111; Tim50. 

Pfam

 PF03031; NIF 

SMART

  

PROSITE

  

PRINTS