CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020602
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SGT1 homolog 
Protein Synonyms/Alias
 Ecdysoneless homolog 
Gene Name
 Ecd 
Gene Synonyms/Alias
 Hsgt1; Sgt1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
463SMKAFISKVSSHKGAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Novel regulator of p53 stability and function (By similarity). May also be a transcriptional activator required for the expression of glycolytic genes. 
Sequence Annotation
 MOD_RES 503 503 Phosphoserine (By similarity).
 MOD_RES 519 519 Phosphoserine (By similarity).  
Keyword
 Activator; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 641 AA 
Protein Sequence
MEGSGKLAMV EDAVEYHLFL IPDKARGTEE HREILQKYIE RIMTQFAPIL VPYIWQNQPF 60
NLKYKPAKGG VPAHMYGMTK FGDNIEDEWF IVYVIKQITK EFPELVARVE DNDGEFLLIE 120
AADFLPKWLD PDNSANRVFF HHGELCIIPV PRKSERIPWL PMTPPTIQQA LSIISAHPEA 180
VLASESIQAA VDRRVSGYPE RVEASLHRAH CFLPAGIVAV LKQQPRLLSA AVQAFYLRDP 240
IDLRACRVFK TFLPETRIMA SVTFTKCLYA QLVQQKFVPD RRSGYGLPPP SHPQYRAYEL 300
GMKLAHGFEI LCSKCSPHFS DSRKSLVTAS PLWASFLESL KRNDYFKGLM DGSAQYQERL 360
EMAKNYFQLS IHRPESSLAM SPGEEILTVL QTQPFDVAEL KTEEADLPPE DDDQWLDLSP 420
DQLDQLLQDA AGRKESQPGP QKEELQNYDV AQVSDSMKAF ISKVSSHKGA ELPRDPSEAP 480
ITFDADSFLN YFDKILGAKP QESDSEDDPG EEDVEGVDSD DDVGFEAQES ESLKGALGSL 540
KSYMARMDQE LAHTSMGRSF TTRERLNKDP PSHTANDNSD EEDSGAGDCA VEAVDVDLNL 600
ISNILESYSS QAGLAGPASN LLHSMGVRLP DNADHNPQVS Q 641 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008283; P:cell proliferation; IMP:MGI.
 GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR010770; SGT1. 
Pfam
 PF07093; SGT1 
SMART
  
PROSITE
  
PRINTS