| Tag | Content |
|---|
| CPLM ID | CPLM-015520 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inhibitor of Bruton tyrosine kinase |
Protein Synonyms/Alias | IBtk |
Gene Name | Ibtk |
Gene Synonyms/Alias | Kiaa1417 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 461 | TQDGEGFKGKWFEDK | ubiquitination | [1] | | 930 | DLSIFYRKMIPAMER | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity). |
Sequence Annotation | REPEAT 51 80 ANK 1.
REPEAT 85 114 ANK 2.
REPEAT 141 194 RCC1 1.
REPEAT 195 246 RCC1 2.
REPEAT 248 301 RCC1 3.
DOMAIN 565 645 BTB 1.
DOMAIN 769 837 BTB 2.
MOD_RES 991 991 Phosphoserine (By similarity).
MOD_RES 998 998 Phosphothreonine.
MOD_RES 1005 1005 Phosphoserine (By similarity).
MOD_RES 1046 1046 Phosphoserine.
MOD_RES 1055 1055 Phosphoserine (By similarity).
MOD_RES 1113 1113 Phosphoserine (By similarity).
MOD_RES 1116 1116 Phosphoserine (By similarity). |
Keyword | Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1352 AA |
Protein Sequence | MDAATPDCTS KCRSLKHALD VLSVVTKGSE SQIKSFLARY CYNAATVKDA FGRNAGHLAS 60
SCGKKGVLDW LIEKGVDLLV KDKESGWTAL HRSVFYGHID CVWSLLKHGV SLYMQDKEGL 120
SPLDLLMKDR PTHVVFKDTD PTEVYTWGDN TNFTLGHGSQ NSKHHPELLD LFSRSGVYVK 180
QVVLCKFHSV FLSQKGQVYT CGHGRGGRLG HGDEQTCLVP RLVEGLSGHN CSQVAAAKDH 240
TVVLTDDGCV YTFGLNMFHQ LGIIPPPASC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT 300
REAVYTLGLN GGQLGHLLDP NGEKCVTTPR QVSALHHKDI AVSLVAASDG ATVCVTTRGD 360
IYLLADYQCK KMATKQLNLK KVLVSGGCME YKVDPEHLTE NGGQKICVLA MDGAGRVFCW 420
RSISSSLKQC RWAYPRQVSI SDIALNRNEI LFVTQDGEGF KGKWFEDKRK NSEKKADILP 480
NLHHSSSDVS CVPDTNSVYE RIRLEKLPFA HRAVSVSTDP SGCNFAILQS DPKTSLYEIP 540
VVSSSSFFEE FGKLLRETDE MDSFHDVTFQ VGNRHFPAHK YILAVRSDFF QKLFLSDGSS 600
LELTDVYQKD EDAAGCHLFV VEKVHPDLFE YLLQFMYTDT CDLLTHGFKP RMIVKRKAED 660
CEGSPDSHLH TVNCHVDDKQ KSAFEVYRSN QAHTLSERQK SKPKSSKKGK GVGDDDPVRM 720
LQSVAKKFGL SNLSSRLEGV RLENEKINVI AKKTGNKLKL SQKKCSFLYD VTMKSVDGKE 780
FSCHKCVLCA RLEYFHSMLS RSWIEASSCA ALEMPIQSEI LKVILDYLYT DEAVVIKESQ 840
NVDFVCSVLV VADQLLITRL KEICEVALTE NLTLKNAAML LEFAALYNAG QLKLSCLQFI 900
GLNMAALLEA RSLDVLSEDV LKDLSIFYRK MIPAMERRVI TPYQDGPDIS SMQVEDGEVF 960
FKEEINMEPN YSETMFKKAK TRAKKKPRKR SDSSGGYTLS DVIQSPPSAG LLKSAKTNSV 1020
ESLPELLTSD SEGSYAGVAS PRDLQSPDFT AGFHSDKVEG KAKPYVNGIP PPCTREDVKP 1080
WEKSPTTKSA PQFIPSNRVD TAASSSWLAG SCSPVSPPVV DLRTIMETEE NRQKYGAAPK 1140
SNLGKIISHG IKLSQKQRKM IALTTKENNS GTNSMEAILT APSKSPKPAN AWAPLHSPLS 1200
RSFRDFLLEE KKPVPGYGSG DHVKKVCFKG TENSPALNVA RCSTHGTPGL ESNHVSDFPL 1260
LDSPNPWQSS SLAASPAVAP VTFASIVEEE RQQEAALIRS REKPLALIQV EEHAIQDLLV 1320
FYEAFGNPEE FVVVERAPQG PLAVPMWNKH GC 1352 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0030292; F:protein tyrosine kinase inhibitor activity; IEA:Compara. GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |