CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030228
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pescadillo homolog 1 
Protein Synonyms/Alias
 Pescadillo homolog 1, containing BRCT domain (Zebrafish), isoform CRA_a; cDNA, FLJ96584, Homo sapiens pescadillo homolog 1, containing BRCT domain(zebrafish) (PES1), mRNA 
Gene Name
 PES1 
Gene Synonyms/Alias
 hCG_2010949 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26TRNKARKKLQLSLADubiquitination[1]
68ARTFYLIKDIRFLLHubiquitination[2]
81LHEPIVNKFREYKVFubiquitination[1, 2]
98KLRKAYGKSEWNTVEubiquitination[1]
441YVPPEKLKLLALQRGubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Nucleus; Ribosome biogenesis; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 588 AA 
Protein Sequence
MGGLEKKKYE RGSATNYITR NKARKKLQLS LADFRRLCIL KGIYPHEPKH KKKVNKGSTA 60
ARTFYLIKDI RFLLHEPIVN KFREYKVFVR KLRKAYGKSE WNTVERLKDN KPNYKLDHII 120
KERYPTFIDA LRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLTVEFMH YIIAARALRK 180
VFLSIKGIYY QAEVLGQPIV WITPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ 240
LLNLHYPPKL EGQAQAEAKA GEGTYALDSE SCMEKLAALS ASLARVVVPA TEEEAEVDEF 300
PTDGEMSAQE EDRRKELEAQ EKHKKLFEGL KFFLNREVPR EALAFIIRSF GGEVSWDKSL 360
CIGATYDVTD SRITHQIVDR PGQQTSVIGR CYVQPQWVFD SVNARLLLPV AEYFSGVQLP 420
PHLSPFVTEK EGDYVPPEKL KLLALQRGED PGNLNESEEE EEEDDNNEGD GDEEGENEEE 480
EEDAEAGSEK EEEARLAALE EQRMEGKKPR VMAGTLKLED KQRLAQEEES EAKRLAIMMM 540
KKREKYLYQK IMFGKRRKIR EANKLAEKRK AHDEAVRSEK KAKKARPE 588 
Gene Ontology
 GO:0000793; C:condensed chromosome; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:InterPro.
 GO:0007000; P:nucleolus organization; IEA:Compara.
 GO:0033365; P:protein localization to organelle; IEA:Compara.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR001357; BRCT_dom.
 IPR010613; Pescadillo. 
Pfam
 PF00533; BRCT
 PF06732; Pescadillo_N 
SMART
 SM00292; BRCT 
PROSITE
 PS50172; BRCT 
PRINTS