UniProt Accession

 H43_MAIZE; Q41811 

Genbank Protein ID

 X84376 

Genbank Nucleotide ID

 CAA59110.1 

Protein Name

 Histone H4.3 

Protein Synonyms/Alias

 HM4 

Gene Name

 H4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Zea mays (Maize) 

NCBI Taxa ID

 4577 

Lysine Modification

Position	Peptide	Type	References
21	GARKRHRKVLRDNIQ	methylation	[1]

Reference

 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 DNA_BIND 17 21
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 6 6 N6-acetyllysine (By similarity).
 MOD_RES 9 9 N6-acetyllysine (By similarity).
 MOD_RES 13 13 N6-acetyllysine (By similarity).
 MOD_RES 17 17 N6-acetyllysine (By similarity).
 MOD_RES 21 21 N6-acetyllysine; alternate (By
 MOD_RES 21 21 N6-methyllysine; alternate.  

Keyword

 Acetylation; Chromosome; DNA-binding; Methylation; Nucleosome core; Nucleus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.