CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001304
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Flotillin-1 
Protein Synonyms/Alias
  
Gene Name
 FLOT1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51NTLTLNVKSEKVYTRubiquitination[1, 2, 3]
78VKIQGQNKEMLAAACubiquitination[2, 4]
166DYLHSLGKARTAQVQubiquitination[2]
211LSEIEMAKAQRDYELubiquitination[2]
302ERLAEAEKSQLIMQAubiquitination[2]
422SISQVNHKPLRTA**ubiquitination[1, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. 
Sequence Annotation
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 385 385 Phosphoserine.  
Keyword
 Cell membrane; Complete proteome; Endosome; Membrane; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 427 AA 
Protein Sequence
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG 60
VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI 120
YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE 180
AEAKRDAGIR EAKAKQEKVS AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL 240
QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA 300
EKSQLIMQAE AEAASVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE AAQLDMLLEK 360
LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI LTRLPESVER LTGVSISQVN 420
HKPLRTA 427 
Gene Ontology
 GO:0005901; C:caveola; TAS:ProtInc.
 GO:0034451; C:centriolar satellite; IDA:BHF-UCL.
 GO:0005768; C:endosome; IDA:UniProtKB.
 GO:0016600; C:flotillin complex; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0007409; P:axonogenesis; IEA:Compara.
 GO:0072659; P:protein localization to plasma membrane; IEA:Compara.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:Compara. 
Interpro
 IPR001107; Band_7. 
Pfam
 PF01145; Band_7 
SMART
 SM00244; PHB 
PROSITE
  
PRINTS