UniProt Accession

 HBA_HUMAN; P69905; P01922; Q1HDT5; Q3MIF5; Q53F97; Q96KF1; Q9NYR7; Q9UCM0 

Genbank Protein ID

 J00153; J00153; V00491; V00493; V00488; V00516; AF230076; AF525460; DQ431198; DQ431198; AF097635; AF105974; AF349571; AF536204; DQ499017; DQ499018; AK223392; AE006462; AE006462; Z84721; Z84721; BC005931; BC008572; BC032122; BC050661; BC101846; BC101848 

Genbank Nucleotide ID

 AAB59407.1; AAB59408.1; CAA23750.1; CAA23752.1; CAA23748.1; CAA23774.1; AAF72612.1; AAM83102.1; ABD95910.1; ABD95911.1; AAC72839.1; AAC97373.1; AAK37554.1; AAN04486.1; ABF56144.1; ABF56145.1; BAD97112.1; AAK61215.1; AAK61216.1; CAB06554.1; CAB06555.1; AAH05931.1; AAH08572.1; AAH32122.1; AAH50661.1; AAI01847.1; AAI01849.1 

Protein Name

 Hemoglobin subunit alpha 

Protein Synonyms/Alias

 Alpha-globin; Hemoglobin alpha chain 

Gene Name

 HBA1; HBA2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MVLSPADKTNVKAAW	glycation	[1]
17	NVKAAWGKVGAHAGE	acetylation	[2]
17	NVKAAWGKVGAHAGE	glycation	[1]
41	FLSFPTTKTYFPHFD	glycation	[1]
62	QVKGHGKKVADALTN	glycation	[1]

Reference

 [1] Sites of nonenzymatic glycosylation of human hemoglobin A.
 Shapiro R, McManus MJ, Zalut C, Bunn HF.
 J Biol Chem. 1980 Apr 10;255(7):3120-7. [PMID: 7358733]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Involved in oxygen transport from the lung to the various peripheral tissues. 

Sequence Annotation

 METAL 59 59 Iron (heme distal ligand).
 METAL 88 88 Iron (heme proximal ligand).
 MOD_RES 17 17 N6-acetyllysine; alternate.
 CARBOHYD 8 8 N-linked (Glc) (glycation).
 CARBOHYD 17 17 N-linked (Glc) (glycation); alternate.
 CARBOHYD 41 41 N-linked (Glc) (glycation).
 CARBOHYD 62 62 N-linked (Glc) (glycation).  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disease mutation; Glycation; Glycoprotein; Heme; Hereditary hemolytic anemia; Iron; Metal-binding; Oxygen transport; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
 GO:0071682; C:endocytic vesicle lumen; TAS:Reactome.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0031838; C:haptoglobin-hemoglobin complex; IDA:BHF-UCL.
 GO:0005833; C:hemoglobin complex; TAS:UniProtKB.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IEA:InterPro.
 GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW.
 GO:0015701; P:bicarbonate transport; TAS:Reactome.
 GO:0042744; P:hydrogen peroxide catabolic process; IDA:BHF-UCL.
 GO:0015671; P:oxygen transport; TAS:UniProtKB.
 GO:0010942; P:positive regulation of cell death; IDA:BHF-UCL.
 GO:0051291; P:protein heterooligomerization; IDA:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002338; Haemoglobin_a.
 IPR018331; Haemoglobin_alpha_chain.
 IPR002339; Haemoglobin_pi. 

Pfam

 PF00042; Globin 

SMART

  

PROSITE

 PS01033; GLOBIN 

PRINTS

 PR00612; ALPHAHAEM.
 PR00815; PIHAEM.