CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016471
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and BTB domain-containing protein 46 
Protein Synonyms/Alias
 BTB-ZF protein expressed in effector lymphocytes; BZEL; BTB/POZ domain-containing protein 4 
Gene Name
 Zbtb46 
Gene Synonyms/Alias
 Btbd4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
46GKVFKAHKNVLLGSSubiquitination[1]
Reference
 [1] A proteomics approach to identify the ubiquitinated proteins in mouse heart.
 Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ.
 Biochem Biophys Res Commun. 2007 Jun 8;357(3):731-6. [PMID: 17451654
Functional Description
 Function as a transcriptional repressor for PRDM1. 
Sequence Annotation
 DOMAIN 31 99 BTB.
 ZN_FING 418 436 C2H2-type 1.
 ZN_FING 446 468 C2H2-type 2.
 CROSSLNK 46 46 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Complete proteome; Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 600 AA 
Protein Sequence
MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDACVVVEGK VFKAHKNVLL GSSRYFKTLY 60
CQVQKTSDQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR NVIEVMSAAS FLQMTDIVQA 120
CHDFIKAALD ISIKSDASDE LSEFEIGTPA SNSTEALISA VMAGRSISPW LARRTSPANS 180
SGDSAIASCH EGGSSYGKED QEPKADGPDD VSSQSLWPGD VGYGSLRIKE EQISPSHYGG 240
SELPSSKDTA IQNSLSEQGS GDGWQPTGRR KNRKNKETVR HITQQVEEDS QAGSPVPSFL 300
PTSGWPFSSR DSNVDLTVTE ASSLDSRGER AELYAHIDEG LLGGETSYLG PPLTPEKEEA 360
LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP KGAHSLSRKC KFWCVTVSSF 420
GLSTSVQPFR PWSH 434 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:2001199; P:negative regulation of dendritic cell differentiation; IMP:MGI.
 GO:0030853; P:negative regulation of granulocyte differentiation; IMP:MGI.
 GO:0045650; P:negative regulation of macrophage differentiation; IMP:MGI.
 GO:0045656; P:negative regulation of monocyte differentiation; IMP:MGI.
 GO:2001200; P:positive regulation of dendritic cell differentiation; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS