CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004721
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Atrial natriuretic peptide receptor 1 
Protein Synonyms/Alias
 Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A 
Gene Name
 Npr1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
694QGHTLFAKKLWTAPEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand (By similarity). 
Sequence Annotation
 DOMAIN 524 801 Protein kinase.
 DOMAIN 872 1002 Guanylate cyclase.
 BINDING 81 81 Chloride.
 BINDING 113 113 Chloride; via amide nitrogen.
 BINDING 114 114 Chloride; via amide nitrogen.
 MOD_RES 515 515 Phosphoserine.
 MOD_RES 525 525 Phosphoserine.
 MOD_RES 528 528 Phosphothreonine.
 MOD_RES 530 530 Phosphoserine.
 MOD_RES 534 534 Phosphoserine.
 MOD_RES 538 538 Phosphoserine.
 MOD_RES 541 541 Phosphothreonine.
 CARBOHYD 41 41 N-linked (GlcNAc...).
 CARBOHYD 208 208 N-linked (GlcNAc...).
 CARBOHYD 334 334 N-linked (GlcNAc...) (Potential).
 CARBOHYD 375 375 N-linked (GlcNAc...) (Potential).
 CARBOHYD 382 382 N-linked (GlcNAc...) (Potential).
 CARBOHYD 423 423 N-linked (GlcNAc...).
 DISULFID 88 114
 DISULFID 192 241
 DISULFID 451 460  
Keyword
 3D-structure; cGMP biosynthesis; Chloride; Complete proteome; Disulfide bond; Glycoprotein; GTP-binding; Lyase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix; Vasoactive. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1057 AA 
Protein Sequence
MPGSRRVRPR LRALLLLPPL LLLRGGHASD LTVAVVLPLT NTSYPWSWAR VGPAVELALA 60
RVKARPDLLP GWTVRMVLGS SENAAGVCSD TAAPLAAVDL KWEHSPAVFL GPGCVYSAAP 120
VGRFTAHWRV PLLTAGAPAL GIGVKDEYAL TTRTGPSHVK LGDFVTALHR RLGWEHQALV 180
LYADRLGDDR PCFFIVEGLY MRVRERLNIT VNHQEFVEGD PDHYPKLLRA VRRKGRVIYI 240
CSSPDAFRNL MLLALNAGLT GEDYVFFHLD VFGQSLKSAQ GLVPQKPWER GDGQDRSARQ 300
AFQAAKIITY KEPDNPEYLE FLKQLKLLAD KKFNFTVEDG LKNIIPASFH DGLLLYVQAV 360
TETLAQGGTV TDGENITQRM WNRSFQGVTG YLKIDRNGDR DTDFSLWDMD PETGAFRVVL 420
NYNGTSQELM AVSEHKLYWP LGYPPPDVPK CGFDNEDPAC NQDHFSTLEV LALVGSLSLI 480
SFLIVSFFIY RKMQLEKELV SELWRVRWED LQPSSLERHL RSAGSRLTLS GRGSNYGSLL 540
TTEGQFQVFA KTAYYKGNLV AVKRVNRKRI ELTRKVLFEL KHMRDVQNEH LTRFVGACTD 600
PPNICILTEY CPRGSLQDIL ENESITLDWM FRYSLTNDIV KGMLFLHNGA ICSHGNLKSS 660
NCVVDGRFVL KITDYGLESF RDPEPEQGHT LFAKKLWTAP ELLRMASPPA RGSQAGDVYS 720
FGIILQEIAL RSGVFYVEGL DLSPKEIIER VTRGEQPPFR PSMDLQSHLE ELGQLMQRCW 780
AEDPQERPPF QQIRLALRKF NKENSSNILD NLLSRMEQYA NNLEELVEER TQAYLEEKRK 840
AEALLYQILP HSVAEQLKRG ETVQAEAFDS VTIYFSDIVG FTALSAESTP MQVVTLLNDL 900
YTCFDAVIDN FDVYKVETIG DAYMVVSGLP VRNGQLHARE VARMALALLD AVRSFRIRHR 960
PQEQLRLRIG IHTGPVCAGV VGLKMPRYCL FGDTVNTASR MESNGEALKI HLSSETKAVL 1020
EEFDGFELEL RGDVEMKGKG KVRTYWLLGE RGCSTRG 1057 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IDA:RGD.
 GO:0004383; F:guanylate cyclase activity; IDA:RGD.
 GO:0016941; F:natriuretic peptide receptor activity; IDA:RGD.
 GO:0017046; F:peptide hormone binding; IDA:RGD.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0019901; F:protein kinase binding; IMP:RGD.
 GO:0007166; P:cell surface receptor signaling pathway; IMP:RGD.
 GO:0042417; P:dopamine metabolic process; IMP:RGD.
 GO:0035556; P:intracellular signal transduction; IDA:RGD.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0030828; P:positive regulation of cGMP biosynthetic process; IMP:RGD.
 GO:0007168; P:receptor guanylyl cyclase signaling pathway; IEA:Compara.
 GO:0050880; P:regulation of blood vessel size; IEA:UniProtKB-KW. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR001828; ANF_lig-bd_rcpt.
 IPR011009; Kinase-like_dom.
 IPR001170; Ntpep_rcpt.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom. 
Pfam
 PF01094; ANF_receptor
 PF00211; Guanylate_cyc
 PF07714; Pkinase_Tyr 
SMART
 SM00044; CYCc 
PROSITE
 PS00458; ANF_RECEPTORS
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2
 PS50011; PROTEIN_KINASE_DOM 
PRINTS
 PR00255; NATPEPTIDER.