| Tag | Content |
|---|
| CPLM ID | CPLM-013918 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tensin-3 |
Protein Synonyms/Alias | Tensin-like SH2 domain-containing protein 1 |
Gene Name | Tns3 |
Gene Synonyms/Alias | Tens1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 63 | EKRYDLTKLNPKIMD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration (By similarity). May be involved in cell migration and bone development. |
Sequence Annotation | DOMAIN 1 170 Phosphatase tensin-type.
DOMAIN 175 301 C2 tensin-type.
DOMAIN 1167 1277 SH2.
MOD_RES 332 332 Phosphoserine.
MOD_RES 333 333 Phosphotyrosine.
MOD_RES 632 632 Phosphothreonine (By similarity).
MOD_RES 769 769 Phosphoserine.
MOD_RES 773 773 Phosphotyrosine (By similarity).
MOD_RES 804 804 Phosphoserine (By similarity).
MOD_RES 860 860 Phosphoserine (By similarity).
MOD_RES 894 894 Phosphoserine (By similarity).
MOD_RES 934 934 Phosphoserine.
MOD_RES 1144 1144 Phosphoserine (By similarity).
MOD_RES 1149 1149 Phosphoserine (By similarity).
MOD_RES 1288 1288 Phosphoserine (By similarity).
MOD_RES 1436 1436 Phosphoserine. |
Keyword | Alternative splicing; Cell junction; Complete proteome; Phosphoprotein; Reference proteome; SH2 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1440 AA |
Protein Sequence | MEDSHELDLT YVTERIIAVS FPASCSEESY LHSLQEVTRM LKCKHGDNYL VLNLSEKRYD 60
LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNNDPQ HVVVIHCRGG KGRIGVVISS 120
YMHFTNVSAS ADQALDRFAM KKFYDDKISA LMEPSQKRYV QFLSGLLSGA MKMNTSPLFL 180
HFVIMHGVPS FDTGGACRPF LKLYQAMQPV YTSGIYNVGS ENPSRIRIAI EPAQLLKGDI 240
MVKCYHKKFR SATRDVIFRL QFHTGAVQGY GLLFGKEELD SACKDDRFPD YGKIELVFSA 300
TPEKIQGSEH LYSDQGVTVD YNTADPLIRW DSYENMSADG EVLHTQGPVD GSLYAKVRKK 360
SASDTGIPSS PQGMPATSSP DHGDHTLSVS SDSGHSTASA RTDKTEERLT PGARRGLSPQ 420
EKAELDQLLS GFGLEDSASS HKDMTDMRSK YSGTRHVVPA QVHVNGDAAL KDRETDILDD 480
EMPHHDLHSV DSLGTLSSSE GPQSTHLGPF TCLKSSQNSL LSDGFGNGVA EDHNGVLSPD 540
LGLGVDTLYD RERMCGGREQ KPLQPLLRKP SAPTPVQAYG QSNYSTQTWV RQQQMVAAHQ 600
YSFASDGEAR LGSRSTVDNT GLAQPPPHIP VTPNRGASSR VAVQRGISNG PNPPDTQQLC 660
PGKALQPRFQ DDRVTNGVHQ EPNTGSSPGS PTLDIDQSIE QLNRLILELD PTFEPIPTHL 720
NALGISAVCP DGVGSGLRCS GRLDSVDGPG RSPGRQGDDP IGGRLRKLSI GQYDNDAASQ 780
VTFSKCGWGK AGVDPAPSLG SFSSPEDIKE TVITAYPSDL NMIDGRIPNS KESSMCLTPS 840
FPVSPETPYV KTSPRYPPFS PPEPQLSSPA SLHKGREPRG CPEIISHTVG MSESPVGPKP 900
TMLRADMPAT PNFQQVFASS CTVSSNGPGQ RRESPPSAER QWVESSPKST LTLLGNSHPS 960
ESPLGTHEFC SSGKDSPGLP CFQSSELQAS FHSHELSMSE PQGALPPAGS QTFLGFNTVT 1020
TATSVLPPGE DAGTLLVNSH GTSPAPGTPL LTTGAADNGF LPHNFLTVSP GASSHHSPGL 1080
QNQNVSLPGQ PPLPEKKRAS EGDRSLGSVS PSSSGFSSPH SGSTMSIPFP NVLPDFCKPS 1140
EVASPLPDSP NDKLVIVKFV QDTSKFWYKA DISREQAIAM LKDKAPGSFI VRDSHSFRGA 1200
YGLAMKVATP PPSVLHLNKK AGDLSNELVR HFLIECTPKG VRLKGCSNEP YFGSLTALVC 1260
QHSITPLALP CKLLIPERDP LEEIAENSPQ TAANSAAELL KQGAACNVWY LNSVEMESLT 1320
GHQAVQKALS MTLVQEPPPV STVVHFKVSA QGITLTDNQR KLFFRRHYPV SSVIFCALDP 1380
QDRKWIKDGP SSKVFGFVAR KQGSATDNVC HLFAEHDPEQ PASAIVNFVS KVMIGSPKKI 1440 |
Gene Ontology | GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. GO:0016477; P:cell migration; IMP:MGI. GO:0048286; P:lung alveolus development; IMP:MGI. GO:0008284; P:positive regulation of cell proliferation; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |