CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034360
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 UDP-glucose 6-dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Ugdh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
123DETPEGQKAVRALCAacetylation[1, 2, 3]
123DETPEGQKAVRALCAubiquitination[4]
138VYEHWVPKEKILTTNubiquitination[4]
140EHWVPKEKILTTNTWacetylation[5]
140EHWVPKEKILTTNTWubiquitination[4]
200RIGNKFLKASVGFGGacetylation[5]
262LFNTVTDKKIAILGFacetylation[5]
262LFNTVTDKKIAILGFubiquitination[4]
263FNTVTDKKIAILGFAacetylation[5]
272AILGFAFKKDTGDTRacetylation[5]
288SSSIYISKYLMDEGAubiquitination[4]
303HLHIYDPKVPREQIVubiquitination[4]
364DYERIHKKMLKPAFIacetylation[5]
367RIHKKMLKPAFIFDGacetylation[3, 5]
367RIHKKMLKPAFIFDGubiquitination[4]
397FQIETIGKKVSSKRIubiquitination[4]
413YTPGEIPKFSLQDPPubiquitination[4]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
 Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 426 AA 
Protein Sequence
MVEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNEA RINAWNSPTL PIYEPGLKEV 60
VESCRGKNLF FSTNIDDAIR EADLVFISVL SNPEFLAEGT AIKDLKNPDR VLIGGDETPE 120
GQKAVRALCA VYEHWVPKEK ILTTNTWSSE LSKLAANAFL AQRISSINSI SALCEATGAD 180
VEEVATAIGM DQRIGNKFLK ASVGFGGSCF QKDVLNLVYL CEALNLPEVA RYWQQVIDMN 240
DYQRRRFASR IIDSLFNTVT DKKIAILGFA FKKDTGDTRE SSSIYISKYL MDEGAHLHIY 300
DPKVPREQIV VDLSHPGVSA DDQVSRLVTI SKDPYEACDG AHALVICTEW DMFKELDYER 360
IHKKMLKPAF IFDGRRVLDG LHSELQTIGF QIETIGKKVS SKRIPYTPGE IPKFSLQDPP 420
NKKPKV 426 
Gene Ontology
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:EC.
 GO:0001702; P:gastrulation with mouth forming second; IMP:MGI. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR017476; Nucleotide_sugar_DH.
 IPR014027; UDP-Glc/GDP-Man_DH_C.
 IPR014026; UDP-Glc/GDP-Man_DH_dimer.
 IPR001732; UDP-Glc/GDP-Man_DH_N. 
Pfam
 PF00984; UDPG_MGDP_dh
 PF03720; UDPG_MGDP_dh_C
 PF03721; UDPG_MGDP_dh_N 
SMART
 SM00984; UDPG_MGDP_dh_C 
PROSITE
  
PRINTS