| Tag | Content |
|---|
| CPLM ID | CPLM-020815 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Angiomotin-like protein 1 |
Protein Synonyms/Alias | junction-enriched and -associated protein; JEAP |
Gene Name | Amotl1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 195 | LPTYEEAKAQSQFFR | ubiquitination | [1] | | 485 | DKLHKFEKELQSISE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus (By similarity). |
Sequence Annotation | MOTIF 965 968 PDZ-binding.
MOD_RES 253 253 Phosphoserine (By similarity).
MOD_RES 307 307 Phosphoserine (By similarity).
MOD_RES 731 731 Phosphoserine.
MOD_RES 804 804 Phosphoserine.
MOD_RES 816 816 Phosphoserine.
MOD_RES 918 918 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Cell junction; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome; Tight junction; Ubl conjugation; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 968 AA |
Protein Sequence | MRRAKSRRGP CEPVLRAPPP ICYSPSSPVQ ILEDPAYFYP DLQLYSGRHE ASTLTVEASG 60
GLRGKSVEDP LSSFHSPNFL RTPEVEMRGS EDVASGRVLQ RLIQEQLRYG TPTENMNLLA 120
IQHQATGSAG PAHATTNFSS TETLTQEDPQ MVYQSARQEP QGQEHQGDNT VMEKQVRSTQ 180
PQQNNEELPT YEEAKAQSQF FRGQQQQQQQ QQQQQQQQQQ QGQGPLSHTY YMAGGTSQKS 240
RTEGRPTVNR ANSGQAHKDE ALKELKQGHV RSLSERIMQL SLERNGAKQH LPSSGNGKSF 300
KAGGEPSPAQ PVCKALDPRG PPPEYPFKTK PMKSPVSKNQ DHGLYYNDQH PGVLHEMVKP 360
YPAPQPARTE VAVLRYQPPP EYGVTSRPCQ LPFPSTVQQH SPMSSQTSSI GGTLHSVSLP 420
LPLPISLAAS QPLPASPNQQ LGPDAFAIVE RAQQMVEILT EENRVLHQEL QGCYDNADKL 480
HKFEKELQSI SEAYESLVKS TTKRESLDKA MRTKLEGEIR RLHDFNRDLR DRLETANRQL 540
SSREYDGHED KAAESHYVSQ NKEFLKEKEK LEMELAAVRT ASEDHRRHIE ILDQALSNAQ 600
ARVIKLEEEL REKQAYVEKV EKLQQALTQL QSACEKRGQM ERRLRTWLER ELDALRTQQK 660
HGTGPPVSLP ECNAPALMEL VREKEERILA LEADMTKWEQ KYLEESTIRH FAMSAAAAAT 720
AERDTTISNH SRNGSYGESS LEAHIWPEEE EVVQANRRCQ DMEYTIKNLH AKIIEKDAMI 780
KVLQQRSRKD AGKTDSASLR PARSVPSIAA ATGTHSRQTS LTSSQLTEEK KEEKTTWKGS 840
IGFLLGKEHQ GQASAPLLPT TPASALSLPA STTSASSTHA KTGSKDSSTQ TDKSTELFWP 900
SMASLPSRGR LSTAPSNSPI LKHPAAKGAV EKQENSPGHG KASEHRGRVS NLLHKPEFPD 960
GEMMEVLI 968 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IDA:MGI. GO:0031410; C:cytoplasmic vesicle; IDA:MGI. GO:0030027; C:lamellipodium; IDA:MGI. GO:0008180; C:signalosome; IEA:Compara. GO:0005923; C:tight junction; IDA:MGI. GO:0003365; P:establishment of cell polarity involved in ameboidal cell migration; IMP:MGI. GO:0035329; P:hippo signaling cascade; IGI:MGI. GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IMP:MGI. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |