CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039864
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cystathionine beta-synthase 
Protein Synonyms/Alias
  
Gene Name
 CBS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89PEKMSSEKVDVLRALubiquitination[1]
123VGVAWRLKNEIPNSHubiquitination[1]
234LDRTVVDKWFKSNDEubiquitination[1]
237TVVDKWFKSNDEEAFubiquitination[1]
296SVRNYMTKFLSDRWMubiquitination[1]
306SDRWMLQKGFLKEEDubiquitination[2]
393QPSDQVGKVIYKQFKubiquitination[1, 3]
397QVGKVIYKQFKQIRLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 463 AA 
Protein Sequence
MVRINKIGKK FGLKCELLAK CEFFNAGGSV KDRISLRMIE DAERDGTLKP GDTIIEPTSG 60
NTGIGLALAA AVRGYRCIIV MPEKMSSEKV DVLRALGAEI VRTPTNARFD SPESHVGVAW 120
RLKNEIPNSH ILDQYRNASN PLAHYDTTAD EILQQCDGKL DMLVASVGTG GTITGIARKL 180
KEKCPGCRII GVDPEGSILA EPEELNQTEQ TTYEVEGIGY DFIPTVLDRT VVDKWFKSND 240
EEAFTFARML IAQEGLLCGG SAGSTVAVAV KAAQELQEGQ RCVVILPDSV RNYMTKFLSD 300
RWMLQKGFLK EEDLTEKKPW WWHLRVQELG LSAPLTVLPT ITCGHTIEIL REKGFDQAPV 360
VDEAGVILGM VTLGNMLSSL LAGKVQPSDQ VGKVIYKQFK QIRLTDTLGR LSHILEMDHF 420
ALVVHEQIQY HSTGKSSQRQ MVFGVVTAID LLNFVAAQER DQK 463 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0004122; F:cystathionine beta-synthase activity; IEA:Compara.
 GO:0001974; P:blood vessel remodeling; IEA:Compara.
 GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0021587; P:cerebellum morphogenesis; IEA:Compara.
 GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
 GO:0019343; P:cysteine biosynthetic process via cystathionine; IEA:InterPro.
 GO:0001958; P:endochondral ossification; IEA:Compara.
 GO:0070814; P:hydrogen sulfide biosynthetic process; IEA:Compara.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0050880; P:regulation of blood vessel size; IEA:Compara.
 GO:0030823; P:regulation of cGMP metabolic process; IEA:Compara.
 GO:0043506; P:regulation of JUN kinase activity; IEA:Compara.
 GO:0051593; P:response to folic acid; IEA:Compara.
 GO:0006801; P:superoxide metabolic process; IEA:Compara.
 GO:0019346; P:transsulfuration; IEA:Compara. 
Interpro
 IPR001216; Cys_synth_BS.
 IPR005857; Cysta_beta_synth.
 IPR000644; Cysta_beta_synth_core.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF. 
Pfam
 PF00571; CBS
 PF00291; PALP 
SMART
 SM00116; CBS 
PROSITE
 PS51371; CBS
 PS00901; CYS_SYNTHASE 
PRINTS