UniProt Accession

 KPRS_ECOLI; P0A717; P08330; P76828; P78058 

Genbank Protein ID

 M13174; U00096; AP009048 

Genbank Nucleotide ID

 AAA24431.1; AAC74291.1; BAA36065.1 

Protein Name

 Ribose-phosphate pyrophosphokinase 

Protein Synonyms/Alias

 RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase 

Gene Name

 prs 

Gene Synonyms/Alias

 prsA; b1207; JW1198 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
182	VRARAIAKLLNDTDM	acetylation	[1, 2, 3]
194	TDMAIIDKRRPRANV	acetylation	[2, 3]
231	DTGGTLCKAAEALKE	acetylation	[2, 3]
237	CKAAEALKERGAKRV	acetylation	[3]
282	IPLSDEIKSLPNVRT	acetylation	[3]

Reference

 [1] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [3] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 REGION 213 226 Binding of phosphoribosylpyrophosphate
 METAL 129 129 Magnesium (Potential).
 METAL 131 131 Magnesium (Potential).
 METAL 140 140 Magnesium (Potential).
 METAL 144 144 Magnesium (Potential).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:HAMAP.
 GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
 GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:HAMAP. 

Interpro

 IPR000842; PRib_PP_synth_CS.
 IPR000836; PRibTrfase_dom.
 IPR005946; Rib-P_diPkinase. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00114; PRPP_SYNTHASE 

PRINTS