UniProt Accession

 KAD1_HUMAN; P00568; Q9BVK9; Q9UQC7 

Genbank Protein ID

 J04809; AB021871; BT019580; BC001116 

Genbank Nucleotide ID

 AAA51686.1; BAA78534.1; AAV38387.1; AAH01116.1 

Protein Name

 Adenylate kinase isoenzyme 1 

Protein Synonyms/Alias

 AK 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase 

Gene Name

 AK1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	QCEKIVQKYGYTHLS	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. 

Sequence Annotation

 NP_BIND 18 23 ATP.
 NP_BIND 65 67 AMP.
 NP_BIND 94 97 AMP.
 REGION 38 67 NMPbind.
 REGION 131 141 LID.
 BINDING 39 39 AMP.
 BINDING 44 44 AMP.
 BINDING 101 101 AMP.
 BINDING 132 132 ATP.
 BINDING 138 138 AMP.
 BINDING 149 149 AMP.
 BINDING 177 177 ATP; via carbonyl oxygen.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Hereditary hemolytic anemia; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0001520; C:outer dense fiber; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0036126; C:sperm flagellum; IEA:Compara.
 GO:0004017; F:adenylate kinase activity; TAS:ProtInc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046034; P:ATP metabolic process; IEA:InterPro.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome. 

Interpro

 IPR000850; Adenylate_kin.
 IPR006267; Adenylate_kin1.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.