CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001222
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Jerky protein homolog 
Protein Synonyms/Alias
  
Gene Name
 JRK 
Gene Synonyms/Alias
 JH8 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25FASSDSNKALEQRRTubiquitination[1]
52LYEWFLGKRSEGVPVubiquitination[1]
162GGAVPGPKQGKDRLTubiquitination[1]
165VPGPKQGKDRLTVLMubiquitination[1]
183ATGSHRLKPLAIGKCubiquitination[1]
189LKPLAIGKCSGPRAFubiquitination[1]
197CSGPRAFKGIQHLPVubiquitination[1]
245IGLPEDSKAVLLLDSubiquitination[1, 2]
375AHILELVKEGSSCPGubiquitination[1]
419EVVWSSEKTPKADQDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 May bind DNA (By similarity). 
Sequence Annotation
 DOMAIN 29 101 HTH CENPB-type.
 DOMAIN 130 334 DDE.  
Keyword
 Complete proteome; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MSTLYDIRAH KAQLLRFFAS SDSNKALEQR RTLHTPKLEH LDRVLYEWFL GKRSEGVPVS 60
GPMLIEKAKD FYEQMQLTEP CVFSGGWLWR FKARHGIKKL DASSEKQSAD HQAAEQFCAF 120
FRSLAAEHGL SAEQVYNADE TGLFWRCLPN PTPEGGAVPG PKQGKDRLTV LMCANATGSH 180
RLKPLAIGKC SGPRAFKGIQ HLPVAYKAQG NAWVDKEIFS DWFHHIFVPS VREHFRTIGL 240
PEDSKAVLLL DSSRAHPQEA ELVSSNVFTI FLPASVASLV QPMEQGIRRD FMRNFINPPV 300
PLQGPHARYN MNDAIFSVAC AWNAVPSHVF RRAWRKLWPS VAFAEGSSSE EELEAECFPV 360
KPHNKSFAHI LELVKEGSSC PGQLRQRQAA SWGVAGREAE GGRPPAATSP AEVVWSSEKT 420
PKADQDGRGD PGEGEEVAWE QAAVAFDAVL RFAERQPCFS AQEVGQLRAL RAVFRSQQQV 480
RRRRGALGAV VKVEALQEGP GGCGATAQSP LPCSSTAGDN 520 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR004875; DDE_SF_endonuclease_CENPB-like.
 IPR009057; Homeodomain-like.
 IPR006600; HTH_CenpB_DNA-bd_dom. 
Pfam
 PF03184; DDE_1
 PF03221; HTH_Tnp_Tc5 
SMART
 SM00674; CENPB 
PROSITE
 PS51253; HTH_CENPB 
PRINTS