UniProt Accession

 DX39A_MOUSE; Q8VDW0; Q3UJV4; Q8C2C2 

Genbank Protein ID

 AK088894; AK145927; AK146294; AK150997; AK162752; AK168079; BC020134 

Genbank Nucleotide ID

 BAC40637.1; BAE26758.1; BAE27051.1; BAE30021.1; BAE37049.1; BAE40052.1; AAH20134.1 

Protein Name

 ATP-dependent RNA helicase DDX39A 

Protein Synonyms/Alias

 DEAD box protein 39 

Gene Name

 Ddx39a 

Gene Synonyms/Alias

 Ddx39 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
240	EIRPVCRKFMQDPME	acetylation	[1]
267	GLQQYYVKLKDSEKN	ubiquitination	[2]
333	LSRYQQFKDFQRRIL	acetylation	[1, 3]
333	LSRYQQFKDFQRRIL	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity). 

Sequence Annotation

 DOMAIN 75 248 Helicase ATP-binding.
 DOMAIN 260 421 Helicase C-terminal.
 NP_BIND 88 95 ATP (By similarity).
 MOTIF 44 72 Q motif.
 MOTIF 195 198 DECD box.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 35 35 N6-acetyllysine (By similarity).
 MOD_RES 171 171 Phosphothreonine (By similarity).
 MOD_RES 426 426 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 427 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006406; P:mRNA export from nucleus; IEA:Compara.
 GO:0000398; P:mRNA splicing, via spliceosome; IEA:Compara. 

Interpro

 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR014014; RNA_helicase_DEAD_Q_motif. 

Pfam

 PF00270; DEAD
 PF00271; Helicase_C 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 

PRINTS