CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005211
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase fused 
Protein Synonyms/Alias
  
Gene Name
 fu 
Gene Synonyms/Alias
 CG6551 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
401RGGGVAAKPIVAPTVacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2. 
Sequence Annotation
 DOMAIN 4 254 Protein kinase.
 NP_BIND 10 18 ATP (By similarity).
 ACT_SITE 125 125 Proton acceptor (By similarity).
 BINDING 33 33 ATP (By similarity).
 MOD_RES 422 422 Phosphoserine.
 MOD_RES 429 429 Phosphoserine.  
Keyword
 ATP-binding; Complete proteome; Developmental protein; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Segmentation polarity protein; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 805 AA 
Protein Sequence
MNRYAVSSLV GQGSFGCVYK ATRKDDSKVV AIKVISKRGR ATKELKNLRR ECDIQARLKH 60
PHVIEMIESF ESKTDLFVVT EFALMDLHRY LSYNGAMGEE PARRVTGHLV SALYYLHSNR 120
ILHRDLKPQN VLLDKNMHAK LCDFGLARNM TLGTHVLTSI KGTPLYMAPE LLAEQPYDHH 180
ADMWSLGCIA YESMAGQPPF CASSILHLVK MIKHEDVKWP STLTSECRSF LQGLLEKDPG 240
LRISWTQLLC HPFVEGRIFI AETQAEAAKE SPFTNPEAKV KSSKQSDPEV GDLDEALAAL 300
DFGESRQENL TTSRDSINAI APSDVEHLET DVEDNMQRVV VPFADLSYRD LSGVRAMPMV 360
HQPVINSHTC FVSGNSNMIL NHMNDNFDFQ ASLRGGGVAA KPIVAPTVRQ SRSKDLEKRK 420
LSQNLDNFSV RLGHSVDHEA QRKATEIATQ EKHNQENKPP AEAISYANSQ PPQQQPQQLK 480
HSMHSTNEEK LSSDNTPPCL LPGWDSCDES QSPPIENDEW LAFLNRSVQE LLDGELDSLK 540
QHNLVSIIVA PLRNSKAIPR VLKSVAQLLS LPFVLVDPVL IVDLELIRNV YVDVKLVPNL 600
MYACKLLLSH KQLSDSAASA PLTTGSLSRT LRSIPELTVE ELETACSLYE LVCHLVHLQQ 660
QFLTQFCDAV AILAASDLFL NFLTHDFRQS DSDAASVRLA GCMLALMGCV LRELPENAEL 720
VERIVFNPRL NFVSLLQSRH HLLRQRSCQL LRLLARFSLR GVQRIWNGEL RFALQQLSEH 780
HSYPALRGEA AQTLDEISHF TFFVT 805 
Gene Ontology
 GO:0035301; C:Hedgehog signaling complex; IPI:FlyBase.
 GO:0016020; C:membrane; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:FlyBase.
 GO:0007293; P:germarium-derived egg chamber formation; IMP:FlyBase.
 GO:0030514; P:negative regulation of BMP signaling pathway; IGI:FlyBase.
 GO:0007228; P:positive regulation of hh target transcription factor activity; IMP:FlyBase.
 GO:0031398; P:positive regulation of protein ubiquitination; IMP:FlyBase.
 GO:0042993; P:positive regulation of transcription factor import into nucleus; IMP:FlyBase.
 GO:0031647; P:regulation of protein stability; IDA:FlyBase.
 GO:0030162; P:regulation of proteolysis; NAS:FlyBase.
 GO:0007367; P:segment polarity determination; IMP:FlyBase. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS