UniProt Accession

 H0VN89_CAVPO; H0VN89 

Genbank Protein ID

 AAKN02019898 

Genbank Nucleotide ID

  

Protein Name

 Ferrochelatase 

Protein Synonyms/Alias

  

Gene Name

 Fech 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Cavia porcellus (Guinea pig) 

NCBI Taxa ID

 10141 

Lysine Modification

Position	Peptide	Type	References
291	TVQKVMEKLSYSNPY	acetylation	[1]

Reference

 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 

Functional Description

 Catalyzes the ferrous insertion into protoporphyrin IX (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Heme biosynthesis; Iron; Lyase; Porphyrin biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 424 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004325; F:ferrochelatase activity; IEA:EC.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0005506; F:iron ion binding; IEA:Compara.
 GO:0030350; F:iron-responsive element binding; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0009589; P:detection of UV; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
 GO:0055072; P:iron ion homeostasis; IEA:Compara.
 GO:0046501; P:protoporphyrinogen IX metabolic process; IEA:Compara.
 GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme; IEA:Compara.
 GO:0046984; P:regulation of hemoglobin biosynthetic process; IEA:Compara.
 GO:0034379; P:very-low-density lipoprotein particle assembly; IEA:Compara. 

Interpro

 IPR001015; Ferrochelatase.
 IPR019772; Ferrochelatase_AS. 

Pfam

 PF00762; Ferrochelatase 

SMART

  

PROSITE

 PS00534; FERROCHELATASE 

PRINTS